Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
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Summary
It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
- Type
- article
- Published
- 2003-08-08
- Cited by
- 4,355
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2148239264
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9699898
Keywords
Neurogenesis, Fluoxetine, Hippocampal formation, Antidepressant, Hippocampus
References
- IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A
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- Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.
- Cognitive dysfunction resulting from hippocampal hyperactivity--a possible cause of anxiety disorder?
- The effects of chronic antidepressant treatment in an animal model of anxiety
- Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests.
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