Signaling to NF-kappaB.
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Summary
An overview of established NF-kappaB signaling pathways is provided with focus on the current state of research into the mechanisms that regulate IKK activation and NF- kappaB transcriptional activity.
- Type
- review
- Published
- 2004-09-15
- Cited by
- 4,013
- References
- 355
- Access
- Open access
- OpenAlex
- https://openalex.org/W2148119611
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30265438
Keywords
Biology, Transcription factor, NF-κB, Signal transduction, IκB kinase
References
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- Structure of NF-κB p50 homodimer bound to a κB site
- Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells.
- SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
- X-ray Crystal Structure of an IκBβ·NF-κB p65 Homodimer Complex*
- JunD mediates survival signaling by the JNK signal transduction pathway.
- The Trimerization Domain of Nemo Is Composed of the Interacting C-terminal CC2 and LZ Coiled-coil Subdomains*
- Activation of NF‐kappa B in vivo is regulated by multiple phosphorylations.
- RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.
- RIP mediates tumor necrosis factor receptor 1 activation of NF‐kappaB but not Fas/APO‐1‐initiated apoptosis.
- Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.
- The oncoprotein Bcl‐3 can facilitate NF‐kappa B‐mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
- IKAP is a scaffold protein of the IκB kinase complex
- A physical and functional map of the human TNF-α/NF-κB signal transduction pathway
- Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
- The IκB Kinase (IKK) Complex Is Tripartite and Contains IKKγ but Not IKAP as a Regular Component*
- All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction.
- The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B.
- IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
- The essential role of MEKK3 in TNF-induced NF-κB activation
Cited by
- The multifaceted oncoprotein Tax: subcellular localization, posttranslational modifications, and NF-κB activation.
- Proteomic characterisation of chronic lymphocytic leukaemia cells treated with rituximab
- Molecular pathogenesis of MALT lymphoma
- Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation
- The biology of immunoglobulin free light chains in kidney disease: a study of Monoclonal and Polyclonal light chains
- Identification of an NF-κB-Dependent Gene Network in Cells Infected by Mammalian Reovirus
- Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics.
- Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-κB activation
- CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
- Regulation of lung inflammation in the model of IgG immune-complex injury.
- Signaling by the Cysteinyl-Leukotriene Receptor 2
- Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65
- Platelet‐Derived Growth Factor‐D Overexpression Contributes to Epithelial‐Mesenchymal Transition of PC3 Prostate Cancer Cells
- SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
- Novel role of curcumin in the prevention of cytokine‐induced islet death in vitro and diabetogenesis in vivo
- Actin cytoskeleton differentially modulates NF-kappaB-mediated IL-8 expression in myelomonocytic cells.
- Platonin inhibits LPS-induced NF-κB by preventing activation of Akt and IKKβ in human PBMC
- NF-kappaB activation through the alternative pathway correlates with chemoresistance and poor survival in extranodal NK/T-cell lymphoma, nasal type.
- Full‐length sequence and expression analysis of a myeloid differentiation factor 88 (MyD88) in half‐smooth tongue sole Cynoglossus semilaevis
- Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: implication in the redox regulation of TNF-alpha signaling.
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