Pathogenesis of NIDDM: A Balanced Overview
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Summary
Information concerning the loss of first-phase insulin secretion, altered pulsatility of insulin release, and enhanced proinsulin-insulin secretory ratio is discussed as it pertains to altered β-cell function in NIDDM.
- Type
- review
- Published
- 1992-03-01
- Cited by
- 2,274
- References
- 369
- OpenAlex
- https://openalex.org/W2146877877
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29550357
Keywords
Internal medicine, Endocrinology, Insulin, Insulin resistance, Hyperinsulinemia
References
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- Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits.
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- Genetic determinants of myocardial infarction.
- Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin*
- TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.
- Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets
- Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers.
- Clinical features, diagnostic criteria and pathogenesis of diabetes mellitus.
- Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.
- Gliclazide modified release: from once-daily administration to 24-hour blood glucose control.
- Potentiation of Insulin-related Signal Transduction by a Novel Protein-tyrosine Phosphatase Inhibitor, Et-3,4-dephostatin, on Cultured 3T3-L1 Adipocytes*
- Minimal model S(I)=0 problem in NIDDM subjects: nonzero Bayesian estimates with credible confidence intervals.
- Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.
- A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.
- Evidence of impaired adipogenesis in insulin resistance.
- Inhibitory mode of indole-2-carboxamide derivatives against HLGPa: molecular docking and 3D-QSAR analyses.
- Calpain-related diseases.
- Improvement of Insulin Resistance and Insulin Secretion by Water Extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% Pancreatectomized Rats
- Measurement of insulin sensitivity in Type 2 diabetes mellitus: comparison between KITT and HOMA‐%S indices and evaluation of their relationship with the components of the insulin resistance syndrome
- Comparison of Hormone and Glucose Responses of Overweight Women to Barley and Oats
- Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons.
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