GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

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Summary

It is shown that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon and suppresses NF-κB activation in normal and cancer colon cell lines as well as in normal mouse colon.

Type
article
Published
2009-03-10
Cited by
709
References
42
Access
Open access

Keywords

Butyrate, Cancer research, Apoptosis, Receptor, Colorectal cancer

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