GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
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Summary
It is shown that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon and suppresses NF-κB activation in normal and cancer colon cell lines as well as in normal mouse colon.
- Type
- article
- Published
- 2009-03-10
- Cited by
- 709
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2145159460
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:166494
Keywords
Butyrate, Cancer research, Apoptosis, Receptor, Colorectal cancer
References
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- Procainamide Is a Specific Inhibitor of DNA Methyltransferase 1*
Cited by
- Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
- A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate
- Nutrient sensing, signal transduction and immune responses.
- Dietary Fiber Treatment Corrects the Composition of Gut Microbiota, Promotes SCFA Production, and Suppresses Colon Carcinogenesis
- Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner
- [The role of natural dietary compounds in colorectal cancer chemoprevention].
- Effect of the prebiotics nutriose FB 06 and raftilose P95 upon the uptake of the short-chain fatty acid butyrate and upon its effect on cell proliferation, viability and differentiation in IEC-6 cells
- Gut microbial short-chain fatty acids in host defense and immune regulation
- Microbial regulation of allergic inflammation
- Biological and pharmacological roles of HCA receptors.
- Epidemiological approaches to understanding complex diseases: Applications in congenital heart disease and cancer
- Screening of Different Organs of Rats for HCA2 Receptor mRNA
- The Microbiome and Its Potential as a Cancer Preventive Intervention
- Short-chain fatty acids in control of body weight and insulin sensitivity
- Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
- Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumor suppressor in colon that protects against colitis and colon cancer under low-fiber dietary conditions
- Differential effects of propionate or β-hydroxybutyrate on genes related to energy balance and insulin sensitivity in bovine white adipose tissue explants from a subcutaneous and a visceral depot.
- The role of short-chain fatty acids in health and disease.
- Re-discovering periodontal butyric acid: New insights on an old metabolite.
- Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells
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