SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter.
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Summary
The identification of SLC5A8 as a tumor suppressor gene in colorectal cancer marks, for the first time, the association of a plasma membrane transporter with tumor suppressive properties.
- Type
- review
- Published
- 2006-04-18
- Cited by
- 190
- References
- 50
- OpenAlex
- https://openalex.org/W2036547532
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5925732
Keywords
Butyrate, Transporter, Monocarboxylate transporter, Cell biology, Acetylation
References
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- Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate
- Modulation of sensitivity to doxorubicin by the histone deacetylase inhibitor sodium butyrate in breast cancer cells.
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- APC, Signal transduction and genetic instability in colorectal cancer
- Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer
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- Histone deacetylases and cancer: causes and therapies
- Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.
- Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2).
- Augmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor
Cited by
- The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein.
- Thermodynamic and structural characterization of the interaction between WD-40 repeat protein 5 (WDR5) and human SET1 family methyltransferases
- A Single-Array-Based Method for Detecting Copy Number Variants Using Affymetrix High Density SNP Arrays and its Application to Breast Cancer
- Effect of the prebiotics nutriose FB 06 and raftilose P95 upon the uptake of the short-chain fatty acid butyrate and upon its effect on cell proliferation, viability and differentiation in IEC-6 cells
- Short chain fatty acids and colonic health
- Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells
- Gaining insight into microbial physiology in the large intestine: a special role for stable isotopes.
- Immunosenescence and the gut microbiota: the role of probiotics and prebiotics
- Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells.
- Is butyrate the link between diet, intestinal microbiota and obesity‐related metabolic diseases?
- Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities
- Review article: the role of butyrate on colonic function
- Cellular distributions of monocarboxylate transporters: a review.
- The role of short-chain fatty acids in health and disease.
- Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells.
- Cellular expression of a monocarboxylate transporter (MCT1) in the mammary gland and sebaceous gland of mice
- Transport of Nicotinate and Structurally Related Compounds by Human SMCT1 (SLC5A8) and Its Relevance to Drug Transport in the Mammalian Intestinal Tract
- Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells
- LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster
- Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice.
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