Intensive versus conventional glucose control in critically ill patients.
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Summary
In this large, international, randomized trial, it was found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg perDeciliter.
- Type
- article
- Published
- 2009-03-26
- Cited by
- 4,410
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2145053281
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24693161
Keywords
Medicine, Liter, Critically ill, Intensive care unit, Randomization
References
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- Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
- The NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) Study: statistical analysis plan.
- Fitting Single and Mixture of Generalized Lambda Distributions to Data via Discretized and Maximum Likelihood Methods: GLDEX in R
- Intensive insulin therapy in critically ill patients.
- Tight glycaemic control: a prospective observational study of a computerised decision-supported intensive insulin therapy protocol
- Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine.
- Is there more to glycaemic control than meets the eye?
- Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial.
- Insulin‐based regimens decrease mortality rates in critically ill patients: a systematic review
- Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses.
- Tight glycaemic control: a survey of intensive care practice in large English hospitals
- Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity.
- Management of blood glucose in the critically ill in Australia and New Zealand: a practice survey and inception cohort study
- Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year.
- Numerical maximum log likelihood estimation for generalized lambda distributions
- Glycemic control in the intensive care unit: why we should wait for NICE-SUGAR.
- Redefining quality--implications of recent clinical trials.
Cited by
- Meaningful outcome measures in cardiac surgery.
- Evidence based evaluation of immuno-coagulatory interventions in critical care.
- Polytraumaversorgung auf der Intensivstation
- A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study
- Health technology assessment review: Computerized glucose regulation in the intensive care unit - how to create artificial control
- Are signposts in the woods pointing in the right direction?
- Organ dysfunction is associated with hyperglycemia in critically ill children
- Glycemic control: a literature review with implications for perioperative nursing practice.
- Sodium, potassium and glucose management in organ transplantation
- Sugar and stroke: cerebrovascular disease and blood glucose control.
- International recommendations for glucose control in adult non diabetic critically ill patients
- Management of blood glucose in patients with stroke.
- Pilot study of using neutral protamine Hagedorn insulin to counteract the effect of methylprednisolone in hospitalized patients with diabetes.
- Intraoperative glycemic control without insulin infusion during pediatric cardiac surgery for congenital heart disease
- Goal-directed ultrasonography in the intensive care unit: No more excuses!*
- "CAN WE FEED?" A mnemonic to merge nutrition and intensive care assessment of the critically ill patient.
- The accuracy of point-of-care glucose measurement
- Compliance with Surgical Care Improvement Project Blood Glucose—A Marker for Euglycemia, but Does It Put our Patients at Risk?
- Nurse workload in implementing a tight glycaemic control protocol in a UK hospital: a pilot time-in-motion study.
- Management of hyperglycemia in a hospitalized patient with diabetes mellitus and cardiovascular disease.
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