Ischemic cell death in brain neurons.
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Summary
A major unifying thread of the review is a consideration of how the changes occurring during and after ischemia conspire to produce damaging levels of free radicals and peroxynitrite to activate calpain and other Ca(2+)-driven processes that are damaging, and to initiate the apoptotic process.
- Type
- review
- Published
- 1999-01-10
- Cited by
- 3,153
- References
- 1,301
- OpenAlex
- https://openalex.org/W2144918294
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12363049
Keywords
Programmed cell death, DNA laddering, Cell biology, Apoptosis, Biology
References
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- bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.
- Apoptosis: molecular mechanisms and implications for human disease
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- Neural Stem Cell Grafts and the Influence of Apolipoprotein E in a Mouse Model of Global Ischaemia
- The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture.
- Recovery from focal brain ischemia induced by extradural compression in diabetic and non-diabetic rats
- Ubiquitin Activity Following Forebrain Ischemia/Reperfusion in the Rat
- Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali
- Pathways of neuron-astrocyte interactions and their possible role in neuroprotection
- Filament size influences temperature changes and brain damage following middle cerebral artery occlusion in rats
- Suppression of BDNF‐induced expression of neuropeptide Y (NPY) in cortical cultures by oxygen‐glucose deprivation: A model system to study ischemic mechanisms in the perinatal brain
- NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices.
- Oxidative stress induced in rat brain by a combination of 3-nitropropionic acid and global ischemia.
- Effect of Low pH on Glutamate Uptake and Release in Isolated Presynaptic Endings from Rat Brain
- Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats.
- Delayed genomic responses to transient middle cerebral artery occlusion in the rat
- Invited review: Neuroprotective properties of certain beta-adrenoceptor antagonists used for the treatment of glaucoma.
- Endoplasmic Reticulum Dysfunction and Ca2+ Deregulation in Isolated CA1 Neurons during Oxygen and Glucose Deprivation
- The human brain and its neural stem cells postmortem: from dead brains to live therapy
- Insights from molecular investigations of traditional Chinese herbal stroke medicines: implications for neuroprotective epilepsy therapy.
- Effects of the aqueous extract of Bryothamnion triquetrum on chemical hypoxia and aglycemia-induced damage in GT1-7 mouse hypothalamic immortalized cells.
- Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia
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