Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial
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Summary
Estrogen alone or in combination with a progestin improves lipoproteins and lowers fibrinogen levels without detectable effects on postchallenge insulin or blood pressure and in women with a uterus, CEE with cyclic MP has the most favorable effect on HDL-C and no excess risk of endometrial hyperplasia.
- Type
- article
- Published
- 1995-01-18
- Cited by
- 2,313
- References
- 52
- OpenAlex
- https://openalex.org/W2144238512
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:73275470
Keywords
Medicine, Estrogen, Postmenopausal women, Progestin, Internal medicine
References
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- Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins.
- Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor
- Hemostatic factors according to menopausal status and use of hormone replacement therapy.
- Carbohydrate metabolism during hormonal substitution therapy.
- The long-term effect of oral and percutaneous estradiol on plasma renin substrate and blood pressure.
- Compliance with hormone therapy.
- Sex hormones and lipoprotein metabolism.
- Association of Hormone-Replacement Therapy With Various Cardiovascular Risk Factors in Postmenopausal Women
Cited by
- Osteoporotic fractures: background and prevention strategies.
- The relationship of menopausal status and serum ferritin to cardiovascular risk.
- The influence of transdermal oestradiol replacement therapy and medroxyprogesterone acetate on serum lipids and lipoproteins.
- Selective estrogen receptor modulators—A new age of estrogens in cardiovascular disease?
- Current concepts in secondary prevention after acute myocardial infarction
- Behaviour of the carotid wall in menopausal women with and without arterial hypertension.
- Normal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome.
- Risks of coronary heart disease in women: current understanding and evolving concepts.
- Women’s Healthy Lifestyle Project: A Randomized Clinical Trial: Results at 54 Months
- The effects of sequential combined oral 17&bgr;-estradiol norethisterone acetate on insulin sensitivity and body composition in healthy postmenopausal women: a randomized single blind placebo-controlled study
- General and medical factors associated with hormone replacement therapy among women attending menopause clinics in Italy
- Effect of Medroxyprogesterone Acetate on Vascular Inflammatory Markers in Postmenopausal Women Receiving Estrogen
- Menopause and ischaemic stroke: basic, clinical and epidemiological considerations. The role of hormone replacement.
- Post-menopausal osteoporosis.
- Glycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial
- Management of selected lipid abnormalities. Hypertriglyceridemia, low HDL cholesterol, lipoprotein(a), in thyroid and renal diseases, and post-transplantation.
- Postmenopausal hormone therapy: the pros and cons
- Effects of raloxifene, one of the selective estrogen receptor modulators, on pituitary-ovary axis and prolactin in postmenopausal women
- Ischemic heart disease in women and the role of hormone therapy.
- Dose of progestin in postmenopausal-combined hormone therapy and risk of endometrial cancer.
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