Natural products as sources of new drugs over the last 25 years.
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Summary
This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
- Type
- review
- Published
- 2007-02-20
- Cited by
- 5,513
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2141474275
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21891259
Keywords
Natural product, Natural (archaeology), Product (mathematics), Drug discovery, Computer science
References
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- Diversity-oriented synthesis; a challenge for synthetic chemistsElectronic supplementary information (ESI) available: Excel file of all the FDA new molecular entities between the years 1998 and July 2003, and new drug approvals between the years 1990 and 2002. See http://www.rsc.org/suppdata/ob/b3/b310752n/
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