A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Explore this paper's citation graph
Summary
It is demonstrated that the SASP can cause paracrine senescence and impact on tumour suppression andSenescence in vivo and TGF-β ligands play a major role by regulating p15INK4b and p21CIP1.
- Type
- article
- Published
- 2013-06-16
- Cited by
- 2,079
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2140930678
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17412260
Keywords
Paracrine signalling, Senescence, Cell biology, Inflammasome, Biology
References
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- Unbiased characterization of the senescence-associated secretome using SILAC-based quantitative proteomics.
- Senescence of activated stellate cells limits liver fibrosis
- Abnormal angiogenesis but intact hematopoietic potential in TGF‐β type I receptor‐deficient mice
- The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development.
- Cellular senescence: when bad things happen to good cells
- Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
- Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
- Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
- Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
- Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
- The serial cultivation of human diploid cell strains.
- Senescence-messaging secretome: SMS-ing cellular stress
- Cellular senescence and cancer treatment.
- Inflammasomes in carcinogenesis and anticancer immune responses
- Radiation-induced bystander signalling in cancer therapy
- Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
- Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Cited by
- The senescence arrest program and the cell cycle.
- Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
- Melatonin regulates PARP1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
- Senescent cells and osteoarthritis: a painful connection
- Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
- The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2
- Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling
- Chemical Strategies for the Detection and Elimination of Senescent Cells
- The importance of integrated therapies on cancer: Silibinin, an old and new molecule
- Role of SIRT1 in Vascular Complications of Diabetes
- Pathway Profiling Of Replicative And Induced Senescence
- Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential.
- In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency
- Ejercicio y envejecimiento: cambios transcripcionales y epigenéticos en un modelo murino de envejecimiento acelerado
- Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells.
- A genetic screening identifies a component of the SWI/SNF complex, Arid1b as a senescence regulator
- Cellular senescence and liver cancer: a gut microbial connection
- The Senescent Cell Induced Bystander Effect
- Interactions between mitochondria and inflammatory factors during cellular senescence
- Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation
Related papers
- Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells
- Autocrine/paracrine function of parathyroid hormone-related peptide in rat osteoblast-like cells.
- Renal autocrine and paracrine signaling -a story of self-protection.
- The possible role of IL—1 autocrine and paracrine in mesangial cell(MSc)
- Autocrine/paracrine involvement of insulin‐like growth factor‐I and its receptor in chronic lymphocytic leukaemia
- Cellular Fate Decision by Autocrine and Paracrine in Tumor
- Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain
- Autocrine and paracrine growth inhibitors of breast cancer cells