Cause or Effect? Selective Serotonin Reuptake Inhibitors and Falls in Older Adults: A Systematic Review
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Summary
There is no Level 1 evidence that SSRIs cause falls, and changes in the current treatment guidelines or policies on the use of SSRIs in older adults based on fall risk may not be justified at this time given the lack of an established evidence base.
- Type
- review
- Published
- 2014-11-25
- Cited by
- 75
- References
- 113
- Access
- Open access
- OpenAlex
- https://openalex.org/W2140451359
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205660780
Keywords
Falls in older adults, Serotonin Uptake Inhibitors, Serotonin, Medicine, Psychology
References
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- The prevalence of anxiety in older adults: methodological issues and a review of the literature.
- Selective Serotonin Reuptake Inhibiting Antidepressants Are Associated With an Increased Risk of Nonvertebral Fractures
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- Detecting Treatment Emergent Adverse Events in Clinical Trials
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- Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study.
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- Effects of nortriptyline and paroxetine on postural sway in depressed elderly patients.
Cited by
- A Status Update on the Association Between Antidepressants and Fractures: Breaking Up?
- Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team
- A Meta-Analysis Investigating Falls in Older Adults Taking Selective Serotonin Reuptake Inhibitors Confirms an Association but by No Means Implies Causation.
- Falls in older adults with major depressive disorder (MDD): a systematic review and exploratory meta-analysis of prospective studies
- Response to Stubbs's Letter to the Editor.
- Depression and Reduced Bone Mineral Density at the Hip and Lumbar Spine: A Comparative Meta-Analysis of Studies in Adults 60 Years and Older
- Antidepressants and Driving in Older Adults: A Systematic Review
- Patterns of selective serotonin reuptake inhibitor use and risk of falls and fractures in community-dwelling elderly people: the Three-City cohort
- Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder - A systematic review and a meta-analysis.
- Older adults’ perspectives on clinical research: a focus group and survey study
- Do Selective Serotonin Reuptake Inhibitors (SSRIs) Cause Fractures?
- Non-tricyclic/non-selective serotonin reuptake inhibitor antidepressants and recurrent falls in frail older women
- Prenatal stress changes courtship vocalizations and bone mineral density in mice.
- Psychotropic Drug-Related Fall Incidents in Nursing Home Residents Living in the Eastern Part of The Netherlands
- Management of Depression in Parkinson's Disease: A Systematic Review
- Association of psychotropic drug use with falls among older adults in Germany. Results of the German Health Interview and Examination Survey for Adults 2008-2011 (DEGS1)
- Association between Antidepressants and Fall-Related Injuries among Long-Term Care Residents.
- Alternative Facts? Antidepressants and Falls in Older Adults.
- Exercise and Older Adults.
- Late-life depression: issues for the general practitioner
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