Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
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Summary
The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
- Type
- article
- Published
- 2010-03-03
- Cited by
- 2,086
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W2140206763
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4416465
Keywords
Immunology, Innate immune system, Biology, Acquired immune system, Immunity
References
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- Basophil effector function and homeostasis during helminth infection.
- Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
- Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.
- IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.
- Regulation of pathogenesis and immunity in helminth infections
- Treatment strategies for allergy and asthma
- A distinct role for interleukin-13 in Th2-cell-mediated immune responses.
- The role of basophils in helminth infection.
- On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites
- The role of T lymphocytes in the pathogenesis of asthma.
- Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
- RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
- MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity
- Simple and highly efficient BAC recombineering using galK selection
- Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4+ T cells
- Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
- Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2–mediated Responses
- A highly efficient recombineering-based method for generating conditional knockout mutations.
Cited by
- Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses
- Innate lymphoid cells: emerging insights in development, lineage relationships, and function.
- IL-33 Signaling Regulates Innate and Adaptive Immunity to Cryptococcus neoformans
- Type 2 innate lymphoid cells control eosinophil homeostasis
- Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor
- Transcription factors controlling development and function of innate lymphoid cells.
- Airway responses towards allergens – from the airway epithelium to T cells
- Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes.
- Inflammatory ILC2 cells: disguising themselves as progenitors?
- IL-4 and IL-13 Signaling in Allergic Airway Disease
- Crosstalk between type 3 innate lymphoid cells and the gut microbiota in inflammatory bowel disease
- Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells.
- Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone.
- Immune Modules Shared by Innate Lymphoid Cells and T Cells
- Sentinels of the type 2 immune response
- Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response
- Epithelial cell–derived cytokines: more than just signaling the alarm
- Association between Adipose Tissue Interleukin-33 and Immunometabolic Markers in Individuals with Varying Degrees of Glycemia
- Immune System Investigation Using Parasitic Helminths
- Immunologic therapeutic interventions in asthma: impact on natural history.
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