Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression
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Summary
When these ligands were tested for teratogenic effects on zebra fish and Xenopus embryos, it was found that coadministration of the RXR and RAR ligands caused more severe abnormalities in these embryos than either ligand alone, providing biological support for the synergistic action of the two ligands.
- Type
- article
- Published
- 1997-02-01
- Cited by
- 181
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2138096813
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31949088
Keywords
Retinoid X receptor, Retinoid X receptor alpha, Biology, Retinoid X receptor beta, Retinoic acid
References
- Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors (*)
- Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs.
- Activation function 2 (AF‐2) of retinoic acid receptor and 9‐cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF‐2 activity.
- Retinoic acid‐mediated down‐regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo.
- RXRalpha‐null F9 embryonal carcinoma cells are resistant to the differentiation, anti‐proliferative and apoptotic effects of retinoids.
- Steroid binding activity is retained in a 16-kDa fragment of the steroid binding domain of rat glucocorticoid receptors.
- Ligand-dependent synergy of thyroid hormone and retinoid X receptors.
- Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.
- Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.
- Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.
- Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism.
- Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand
- Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells
- Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes
- RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells
- Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping
- Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo
- Retinoic acid causes an anteroposterior transformation in the developing central nervous system
- Enhancement of HL-60 Differentiation by a New Class of Retinoids with Selective Activity on Retinoid X Receptor (*)
- Identification of a nuclear receptor that is activated by farnesol metabolites.
Cited by
- Characterization of Receptor-interacting Protein 140 in Retinoid Receptor Activities*
- Retinoids, rexinoids and their cognate nuclear receptors: character and their role in chemoprevention of selected malignant diseases.
- Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons
- Retinoic acid receptors: structural basis for coregulator interaction and exchange.
- Immediate-Early Response Genes as Targets for Breast Cancer Treatment
- Retinoic Acid Metabolism Blocking Agents and the Skin : In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis
- Molecular Biology of Steroid and Nuclear Hormone Receptors
- 9-cis-Retinoic Acid (9cRA), a Retinoid X Receptor (RXR) Ligand, Exerts Immunosuppressive Effects on Dendritic Cells by RXR-Dependent Activation: Inhibition of Peroxisome Proliferator-Activated Receptor γ Blocks Some of the 9cRA Activities, and Precludes Them to Mature Phenotype Development1
- Transactivation of RARE and GRE in the cellular response to arsenic
- Some aspects of nuclear receptor function in the CNS : Novel roles of Nurr1 and RXR in developing and mature neurons
- Retinoids in the modulation of vascular inflammation
- Retinoid-X receptor signalling in the developing spinal cord
- Molecular mechanisms of metal toxicity and carcinogenesis
- Steroid-induced conformational changes of rat glucocorticoid receptor cause altered trypsin cleavage of the putative helix 6 in the ligand binding domain.
- Role of the Retinoid X Receptors in Skeletal Muscle Development
- Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies
- Modulación del sistema inmune por el ácido docosahexanoico: Efecto sobre la célula dendrítica.
- Vitamin A and infancy. Biochemical, functional, and clinical aspects.
- Retinoid receptors in human esophageal squamous cell carcinoma: Retinoid X receptor as a potent prognostic factor
- Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter
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