Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression

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Summary

When these ligands were tested for teratogenic effects on zebra fish and Xenopus embryos, it was found that coadministration of the RXR and RAR ligands caused more severe abnormalities in these embryos than either ligand alone, providing biological support for the synergistic action of the two ligands.

Type
article
Published
1997-02-01
Cited by
181
References
66
Access
Open access

Keywords

Retinoid X receptor, Retinoid X receptor alpha, Biology, Retinoid X receptor beta, Retinoic acid

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