Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes
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Summary
In keratinocytes, RAR•R XR-mediated pathway dominates over that mediated by RXR•RXR; RAR-selective CD367 and RXR- selective SR11237 can be used to identify these two distinct pathways.
- Type
- article
- Published
- 1995-02-17
- Cited by
- 100
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W1810512602
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33460607
Keywords
Retinoid X receptor, Transactivation, Retinoid, Retinoic acid, Retinoid X receptor alpha
References
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- Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.
- Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements.
Cited by
- Systemic retinoids: chemoprevention of skin cancer in transplant recipients.
- Stimulation of tissue-type plasminogen activator expression by retinoic acid in human endothelial cells requires retinoic acid receptor beta 2 induction.
- All-trans retinoic acid mitigates methotrexate-induced liver injury in rats; relevance of retinoic acid signaling pathway
- Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications
- The role of retinoid signaling in the song control system of the zebra finch
- Molecular mechanisms of retinoid actions in skin
- RXR- and RAR-selective retinoids in psoriasis and (pre)malignant skin disorders
- Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand
- Progressive decreases in nuclear retinoid receptors during skin squamous carcinogenesis.
- Metabolism of all-trans-retinol in normal human cell strains and squamous cell carcinoma (SCC) lines from the oral cavity and skin: reduced esterification of retinol in SCC lines.
- Mechanistic studies to evaluate the enhanced antiproliferation of human keratinocytes by 1alpha,25-dihydroxyvitamin D(3)-3-bromoacetate, a covalent modifier of vitamin D receptor, compared to 1alpha,25-dihydroxyvitamin D(3).
- Promoter Architecture, Cofactors, and Orphan Receptors Contribute to Cell-specific Activation of the Retinoic Acid Receptor β2 Promoter*
- Developments in topical retinoid therapy for acne.
- Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes.
- Association of the PPAR-γ Gene with Altered Glucose Levels and Psychosis Profile in Schizophrenia Patients Exposed to Antipsychotics
- Photoreaction, Phototoxicity, and Photocarcinogenicity of Retinoids
- Retinoic acid signaling cascade in differentiating murine epidermal keratinocytes: Alterations in papilloma‐ and carcinoma‐derived cell lines
- Neural Epidermal Growth Factor-Like Like Protein 2 (NELL2) Promotes Aggregation of Embryonic Carcinoma P19 Cells by Inducing N-Cadherin Expression
- Retinoid induction of CRABP II mRNA in human dermal fibroblasts: use as a retinoid bioassay.
- Disruption of Vitamin D Receptor-Retinoid X Receptor Heterodimer Formation following ras Transformation of Human Keratinocytes*
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