Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
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Summary
Organic osmolytes are small solutes used by cells of numerous water-stressed organisms and tissues to maintain cell volume and have applications in biotechnology, agriculture and medicine, including in vitro rescue of the misfolded protein of cystic fibrosis.
- Type
- review
- Published
- 2005-08-01
- Cited by
- 1,775
- References
- 74
- Access
- Open access
- OpenAlex
- https://openalex.org/W2135684970
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18851977
Keywords
Osmolyte, Osmoprotectant, Biochemistry, Trehalose, Hypotaurine
References
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- Preventing misfolding of the prion protein by trimethylamine N-oxide.
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- The osmophobic effect: natural selection of a thermodynamic force in protein folding.
- Comparative Physiological Evidence that beta-Alanine Betaine and Choline-O-Sulfate Act as Compatible Osmolytes in Halophytic Limonium Species.
Cited by
- Crosstalk between the ER stress pathway and osmotic stress in S. cerevisiae
- Ultraviolet A induces transport of compatible organic osmolytes in human dermal fibroblasts
- The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions.
- Trehalose Metabolism: From Osmoprotection to Signaling
- Betaines and Dimethylsulfoniopropionate as Major Osmolytes in Cnidaria with Endosymbiotic Dinoflagellates
- A role for inositol monophosphatase 1 (IMPA1) in salinity adaptation in the euryhaline eel (Anguilla anguilla)
- Drought, metabolites, and Arabidopsis natural variation: a promising combination for understanding adaptation to water-limited environments.
- The crystal structure of the substrate-binding protein OpuBC from Bacillus subtilis in complex with choline.
- Does the crowded cell-like environment reduce the chaperone-like activity of α-crystallin?
- Trimethylamine N-Oxide as a Media Supplement for Cartilage Tissue Engineering
- Mild desiccation rapidly increases freeze tolerance of the goldenrod gall fly, Eurosta solidaginis: evidence for drought-induced rapid cold-hardening
- The effect of aqueous solutions of trimethylamine-N-oxide on pressure induced modifications of hydrophobic interactions.
- Biomarkers of Whale Shark Health: A Metabolomic Approach
- Deletion of TRAAK Potassium Channel Affects Brain Metabolism and Protects against Ischemia
- Physiological and molecular mechanisms of salt and water homeostasis in the nematode Caenorhabditis elegans.
- Tissue Depletion of Taurine Accelerates Skeletal Muscle Senescence and Leads to Early Death in Mice
- Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis
- Chemical Derivatization of Metabolite Mass Profiling of the Recretohalophyte Aeluropus lagopoides Revealing Salt Stress Tolerance Mechanism
- Metabolic Adjustment of Arabidopsis Root Suspension Cells During Adaptation to Salt Stress and Mitotic Stress Memory
- Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments
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