Hypercholesterolemia increases endothelial superoxide anion production.
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Summary
Increased endothelial O2- production in HV may inactivate endothelium-derived nitric oxide and provide a source for other oxygen radicals, contributing to the early atherosclerotic process.
- Type
- article
- Published
- 1993-06-01
- Cited by
- 1,857
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2135633069
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11741536
Keywords
Superoxide, Xanthine oxidase, Lucigenin, Chemistry, Nitric oxide
References
- Superoxide anion release by human endothelial cells: Synergism between a phorbol ester and a calcium ionophore
- Atherosclerosis Impairs Endothelium‐Dependent Vascular Relaxation to Acetylcholine and Thrombin in Primates
- Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.
- Coronary vascular reactivity after acute myocardial ischemia.
- Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity.
- Mediator‐induced activation of xanthine oxidase in endothelial cells
- Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase.
- Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation.
- The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.
- Nitroblue Tetrazolium Reduction in Lymphocytes
- Lucigenin chemiluminescence in the assessment of neutrophil superoxide production.
- The extinction coefficient of cytochrome c.
- Attenuation of endothelium-dependent relaxation in aorta from diabetic rats.
- Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.
- Oxidation and reduction of hemoproteins by trioxodinitrate(II). The role of nitrosyl hydride and nitrite
- Cholesterol feeding impairs endothelium-dependent relaxation of rabbit aorta.
- Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity.
- Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
- Superoxide radicals as precursors of mitochondrial hydrogen peroxide
- Endothelium‐Dependent Vasodilation Is Attenuated in Patients With Heart Failure
Cited by
- Myokardiale Perfusion unter H.E.L.P.-Apherese
- Endothelial Dysfunction in Essential Hypertension
- Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation.
- Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.
- Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits.
- Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction.
- p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats.
- Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury.
- Burst production of superoxide anion in human endothelial cells by lysophosphatidylcholine.
- Effects of cholesterol-lowering treatments on oxidative modification of plasma intermediate density lipoprotein plus low density lipoprotein fraction in Type 2 diabetic patients.
- Vitamin E and vascular homeostasis: implications for atherosclerosis
- Cholesterol lowering and endothelial function.
- Lipid peroxidation and glutathione system in hyperlipemic rabbits: influence of olive oil administration.
- Folic acid reverts dysfunction of endothelial nitric oxide synthase.
- Endothelial dysfunction in arterial hypertension
- 'It all used to be so simple in the old days'; a personal view.
- Select Flavonoids and Whole Juice From Purple Grapes Inhibit Platelet Function and Enhance Nitric Oxide Release
- The use of statins in acute coronary syndromes: The mechanisms behind the outcomes
- Peroxynitrite-modified 99mTc-beta-VLDL: tissue distribution and plasma clearance rate.
- Antioxidant Improves Smooth Muscle Sarco/Endoplasmic Reticulum Ca2+-ATPase Function and Lowers Tyrosine Nitration in Hypercholesterolemia and Improves Nitric Oxide–Induced Relaxation
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