A circadian gene expression atlas in mammals: Implications for biology and medicine
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Summary
High-resolution multiorgan expression data is generated showing that nearly half of all genes in the mouse genome oscillate with circadian rhythm somewhere in the body, and the majority of best-selling drugs and World Health Organization essential medicines directly target the products of rhythmic genes.
- Type
- article
- Published
- 2014-10-27
- Cited by
- 2,097
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2133918896
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12446359
Keywords
Circadian rhythm, Biology, Gene, Circadian clock, Gene expression
References
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- Circadian clocks and neurodegenerative diseases: time to aggregate?
- Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver
- Extraction of semantic biomedical relations from text using conditional random fields
- Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update
- PI3K/Akt: getting it right matters
- LifeMap Discovery™: The Embryonic Development, Stem Cells, and Regenerative Medicine Research Portal
- In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism
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- Principles for circadian orchestration of metabolic pathways
- The flexible clock: predictive and reactive homeostasis, energy balance and the circadian regulation of sleep–wake timing
- Looking to the future of organs-on-chips: interview with Professor John Wikswo
- Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study
- ExpressionDB: An open source platform for distributing genome-scale datasets
- Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes
- Co-existing feedback loops generate tissue-specific circadian rhythms
- The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction
- Comprehensive RNA-Seq Profiling Reveals Temporal and Tissue-Specific Changes in Gene Expression in Sprague–Dawley Rats as Response to Heat Stress Challenges
- Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach
- Chemical chronobiology: Toward drugs manipulating time
- Confidence in Phase Definition for Periodicity in Genes Expression Time Series
- An Integrated View of Potassium Homeostasis
- Circadian systems biology: When time matters
- Towards a systems view of IBS
- Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus.
- The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle
- Building and mining an atlas of the mammalian circadian transcriptome
- Widespread seasonal gene expression reveals annual differences in human immunity and physiology
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