Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.
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Summary
These findings indicate that BMAL1 in a complex with CLOCK or NPAS2 regulates cerebral redox homeostasis and connects impaired clock gene function to neurodegeneration.
- Type
- article
- Published
- 2013-12-02
- Cited by
- 472
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2003062381
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3371627
Keywords
Neurodegeneration, Circadian rhythm, Circadian clock, Homeostasis, Biology
References
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- Role of the CLOCK protein in the mammalian circadian mechanism.
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- Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity
- Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
- NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
- Obesity in mice with adipocyte-specific deletion of clock component Arntl
- Circadian clock protein BMAL1 regulates cellular senescence in vivo
- Circadian control by the reduction/oxidation pathway: Catalase represses light-dependent clock gene expression in the zebrafish
Cited by
- Clock Genes Control Cortical Critical Period Timing
- Bmal1 knockdown suppresses wake and increases immobility without altering orexin A, corticotrophin‐releasing hormone, or glutamate decarboxylase
- Mood-related central and peripheral clocks
- The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction
- Analysis of the redox oscillations in the circadian clockwork
- The application and challenges of RNA-sequencing to the study of circadian rhythms
- Drosophila Spaghetti and Doubletime Link the Circadian Clock and Light to Caspases, Apoptosis and Tauopathy
- Nuclear redox imbalance affects circadian oscillation in HaCaT keratinocytes.
- Chronobiology of the hair follicle:Dissecting the role of BMAL1 and PER1 in the control of human hair growth and pigmentation
- How does healthy aging impact on the circadian clock?
- Building and mining an atlas of the mammalian circadian transcriptome
- Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice
- SIRT1 in neurodevelopment and brain senescence
- Circadian control of β-cell function and stress responses
- The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver
- Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis
- Circadian Clock Genes Are Essential for Normal Adult Neurogenesis, Differentiation, and Fate Determination
- Circadian cycle dependent EEG biomarkers of pathogenicity in adult mice following prenatal exposure to in utero inflammation
- Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease
- Network-Mediated Encoding of Circadian Time: The Suprachiasmatic Nucleus (SCN) from Genes to Neurons to Circuits, and Back
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