Evidence for a central component of post-injury pain hypersensitivity
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Summary
An animal model is developed where changes occur in the threshold and responsiveness of the flexor reflex following peripheral injury that are analogous to the sensory changes found in man, and shows that it in part arises from changes in the activity of the spinal cord.
- Type
- article
- Published
- 1983-12-15
- Cited by
- 2,174
- References
- 6
- OpenAlex
- https://openalex.org/W2132829674
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4344276
Keywords
Nociceptor, Stimulus (psychology), Noxious stimulus, Reflex, Medicine
References
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- THE PHENOMENA OF ANGINA PECTORIS, AND THEIR BEARING UPON THE THEORY OF COUNTER-IRRITATION.
- Unmyelinated nociceptive units in two skin areas of the rat
- The spread of sensitization of polymodal nociceptors in the rabbit from nearby injury and by antidromic nerve stimulation.
- Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat
- Experimental evidence on the nature of cutaneous hyperalgesia.
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- Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury.
- Learned tolerance to ethanol in a spinal reflex separated from supraspinal control.
- Animal models of acute and chronic inflammatory and nociceptive pain.
- Noxious stimuli induce an N‐methyl‐D‐aspartate receptor‐dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia
- Central neural mechanisms mediating human visceral hypersensitivity.
- Effect of preincision versus postincision infiltration with bupivacaine on postoperative pain.
- Postoperative epidural infusion of a mixture of bupivacaine 0.2% with fentanyl for upper abdominal surgery A comparison of thoracic and lumbar routes
- Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat.
- Spinal cord mechanisms of hyperalgesia and allodynia: role of peripheral input from nociceptors.
- Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons.
- Involvement of spinal substance P and excitatory amino acids in inflammatory hyperalgesia in rats.
- Maturation of the biphasic behavioral and heart rate response in the formalin test.
- Transient inhibition of responses to thermal stimuli of spinal sensory tract neurons in monkeys during sensitization by intradermal capsaicin
- Fentanyl Enhancement of Carrageenan-induced Long-lasting Hyperalgesia in Rats: Prevention by the N-methyl-d-aspartate Receptor Antagonist Ketamine
- A review of contralateral responses to a unilateral inflammatory lesion.
- Key role of the dorsal root ganglion in neuropathic tactile hypersensibility
- Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery.
- The role of sodium channels in chronic inflammatory and neuropathic pain.
- Comparison of bupivacaine and ropivacaine on postoperative pain after tonsillectomy in paediatric patients.
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