Noxious stimuli induce an N‐methyl‐D‐aspartate receptor‐dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia
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Summary
The reduction in threshold and the increase in touch responsiveness induced by cutaneous and muscle noxious C‐fiber conditioning stimuli in the rat spinal cord are both prevented and reversed by NMDA receptor antagonism.
- Type
- article
- Published
- 1995-06-01
- Cited by
- 173
- References
- 64
- OpenAlex
- https://openalex.org/W7478681
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21152462
Keywords
Computer science
References
- Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on the responses of rat spinal neurons with joint input.
- Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.
- Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro.
- Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat
- The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury
- N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint.
- The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord.
- N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
- An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice.
- First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist.
- On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat.
- Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex.
- The induction and maintenance of central sensitization is dependent on N‐methyl‐d‐aspartic acid receptor activation; implications for the treatment of post‐injury pain hypersensitivity states
- Thapsigargin blocks the mobilisation of intracellular calcium caused by activation of human NK1 (long) receptors expressed in Chinese hamster ovary cells.
- Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation.
- The effects of a non‐competitive NMDA receptor antagonist, MK‐801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation
- The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
- Muscle but not cutaneous C‐afferent input produces prolonged increases in the excitability of the flexion reflex in the rat.
- Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
- NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw.
Cited by
- The involvement of tachykinin NK2 and NK3 receptors in central sensitization of a spinal withdrawal reflex in the decerebrated, spinalized rabbit.
- Ketamine for acute and subacute pain in opioid-tolerant patients.
- Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.
- Glutamate Receptors and Nociception
- Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
- Animal models of acute surgical pain.
- Retro-Orbital Tumour—An Uncommon Cause of Headache in Pregnancy
- NMDA Receptors and Colitis: Basic Science and Clinical Implications
- A rat model of postthoracotomy pain: behavioural and spinal cord NK-1 receptor assessment
- NMDA Antagonists as Potential Analgesic Drugs
- An investigation into the epigenetic regulation of nociceptive processing
- Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.
- Chapter 14 Descending excitatory systems.
- Effects of Perioperative Low Dose Ketamine Infusion on Postoperative Pain Perception in Males and Females Undergoing Laparoscopic Surgery
- Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain
- Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats
- Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin-Induced Hyperalgesia: Relationship toc-fos Induction
- The transition from naïve to primed nociceptive state: A novel wind-up protocol in mice.
- [Intrathecal drugs for chronic pain control.].
- Interacciones neuroinmunes y dolor neuropático: papel del factor de crecimiento neuronal
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