Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
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Summary
It is shown that senescence-associated secretory phenotype (SASP) has crucial roles in promoting obesity-associated hepatocellular carcinoma (HCC) development in mice, and a similar pathway may contribute to at least certain aspects of obesity- associated HCC development in humans as well.
- Type
- article
- Published
- 2013-06-26
- Cited by
- 2,063
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2132406938
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4410159
Keywords
Gut flora, Cancer, Biology, Enterohepatic circulation, Liver cancer
References
- Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature.
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- Senescence of activated stellate cells limits liver fibrosis
- Cellular toxicity of fecal water depends on diet.
- Inflammation and Liver Cancer
- Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
- Obesity, Inflammation and Liver Cancer
- Cellular senescence in cancer and aging.
- A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.
- Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids.
- The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
- The serial cultivation of human diploid cell strains.
- Senescence-messaging secretome: SMS-ing cellular stress
- Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium
- Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
- Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype
- Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype*
- Molecular mechanisms of cancer development in obesity
- Cancer: Crime and punishment
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Cited by
- Mouse models of liver cancer.
- Epidemiologie und Risikofaktoren des hepatozellulären Karzinoms
- Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH)
- Predictors of malignancies and overall mortality in Japanese patients with biopsy‐proven non‐alcoholic fatty liver disease
- Functional Local Input to Layer 5 Pyramidal Neurons in the Rat Visual Cortex.
- The Gut Microbial Endocrine Organ: Bacterially-Derived Signals Driving Cardiometabolic Diseases
- Combination of body mass index and oxidized low density lipoprotein receptor 1 in prognosis prediction of patients with squamous non-small cell lung cancer
- Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity
- Obesity and Cancer: Concepts and Challenges
- Liver Fibrosis: From Pathogenesis to Novel Therapies
- Role of the Gut Microbiome in Modulating Arthritis Progression in Mice
- Hepatitis B Virus Core Antigen Stimulates IL-6 Expression via p38, ERK and NF-κB Pathways in Hepatocytes
- Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery
- The microbiome and hepatobiliary-pancreatic cancers.
- Deep Brain Stimulation—Possible Treatment Strategy for Pathologically Altered Body Weight?
- Microbiota, Epithelium, Inflammation, and TGF-β Signaling: An Intricate Interaction in Oncogenesis
- Deletion of poly(ADP-ribose) polymerase-1 changes the composition of the microbiome in the gut
- Targeting Endothelial Erk1/2-Akt Axis as a Regeneration Strategy to Bypass Fibrosis during Chronic Liver Injury in Mice.
- Apoptosis and miRNAs in non-alcoholic fatty liver disease pathogenesis
- Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration.
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