MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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Summary
It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
- Type
- article
- Published
- 2008-12-18
- Cited by
- 2,442
- References
- 35
- OpenAlex
- https://openalex.org/W2132093971
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4333547
Keywords
microRNA, Antagomir, Gene silencing, MAPK/ERK pathway, Kinase
References
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Cited by
- Atrial remodeling and atrial fibrillation: recent advances and translational perspectives.
- microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2.
- MicroRNA expression patterns of the kidney in hyperuricemia mice treated with Xiezhuo Chubi Decoction (泄浊除痹方)
- The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs
- Cardiac Insulin Resistance and MicroRNA Modulators
- Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma
- Cardiac Hypertrophy Is Positively Regulated by MicroRNA miR-23a*
- Modulation of immune responses following solid organ transplantation by microRNA
- MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells.
- Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat
- Lentiviral miR30-based RNA Interference against Heparanase Suppresses Melanoma Metastasis with Lower Liver and Lung Toxicity
- MicroRNA-21 regulates stemness in cancer cells
- MicroRNAs: their involvement in fibrosis pathogenesis and use as diagnostic biomarkers in scleroderma
- Matrix as an Interstitial Transport System
- MicroRNA‑21 regulation of the progression of viral myocarditis to dilated cardiomyopathy.
- The role of microRNAs during hepatitis C viral infection and liver regeneration
- Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload
- Cardioprotective Effect of MicroRNA-21 in Murine Myocardial Infarction.
- miR-21 and cardiac fibrosis: another brick in the wall?
- Connexin and fibrosis related microRNAs in complex fractionated atrial electrograms
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