Quantitative estimation of insulin sensitivity.
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Summary
From a single glucose injection it is possible to obtain a quantitative index of insulin sensitivity that may have clinical applicability, and this index was defined as the ratio of two parameters of the chosen model and could be estimated with good reproducibility from the 300 mg/kg injection experiments.
- Type
- article
- Published
- 1979-06-01
- Cited by
- 2,027
- References
- 25
- OpenAlex
- https://openalex.org/W2125624587
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27391464
Keywords
Insulin, Insulin sensitivity, Reproducibility, Plasma glucose, Sensitivity (control systems)
References
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- RENAL TUBULAR EXCRETION
- Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting.
- A new look at the statistical model identification
Cited by
- A Closed-Loop Artificial Pancreas Using Model Predictive Control and a Sliding Meal Size Estimator
- Androgen response to endogenous insulin secretion during the frequently sampled intravenous glucose tolerance test in normal and hyperandrogenic women.
- Effects of short-term pulsatile and continuous insulin delivery on glucagon secretion and insulin secretion and action.
- TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.
- Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: evidence for a concentration-dependent defect in uptake.
- No deterioration in insulin sensitivity, but impairment of both pancreatic β‐cell function and glucose sensitivity, in Japanese women with former gestational diabetes mellitus
- Minimal model S(I)=0 problem in NIDDM subjects: nonzero Bayesian estimates with credible confidence intervals.
- Age‐Related Analysis of Glucose Metabolism in Spontaneously Hypertensive and Normotensive Rats
- Glucose Clamp Algorithms and Insulin Time-Action Profiles
- Modeling Approaches to Type 2 Diabetes
- Deterioration of insulin sensitivity and glucose effectiveness with age and hypertension.
- An Integrated Model for Glucose and Insulin Regulation in Healthy Volunteers and Type 2 Diabetic Patients Following Intravenous Glucose Provocations
- Chromium Picolinate Does Not Improve Key Features of Metabolic Syndrome in Obese Nondiabetic Adults
- Optimization of the intravenous glucose tolerance test in T2DM patients using optimal experimental design
- Exercise training in pregnancy reduces offspring size without changes in maternal insulin sensitivity.
- Feedforward-feedback multiple predictive controllers for glucose regulation in type 1 diabetes
- Pharmacokinetic/pharmacodynamic modeling of glucose clamp effects of inhaled and subcutaneous insulin in healthy volunteers and diabetic patients.
- A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
- A Composite Model of Glucagon-Glucose Dynamics for In Silico Testing of Bihormonal Glucose Controllers
- Pankreashormone und Leptin
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