Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
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Summary
It is reported that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells.
- Type
- article
- Published
- 2004-10-01
- Cited by
- 2,644
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2124078079
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14693017
Keywords
Neural stem cell, Stem cell, Biology, Cancer stem cell, Pathology
References
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- Treatment of intracranial glioma with in situ interferon-gamma and tumor necrosis factor-alpha gene transfer
- Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons
- Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation.
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- Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
- Establishment and characterization of a human glioblastoma multiforme cell line.
- Establishment and characterization of a human cell line from paediatric cerebellar glioblastoma multiforme
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
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- Getting at the root and stem of brain tumors.
- Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells.
- Characterization of Purified and Ex Vivo Manipulated Human Hematopoietic Progenitor and Stem Cells in Xenograft Recipients
- Prospective identification of tumorigenic breast cancer cells
Cited by
- Neurosphere Culture and Human Organotypic Model to Evaluate Brain Tumor Stem Cells
- Advances in Cancer Stem Cell Biology
- The potential origin of glioblastoma initiating cells
- Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma
- Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2
- Potent antitumor effect of SN‐38‐incorporating polymeric micelle, NK012, against malignant glioma
- Cellular immortality in brain tumours: an integration of the cancer stem cell paradigm.
- Cancer stem cells in the central nervous system--a critical review.
- Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
- Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity
- Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
- Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.
- The malignant social network
- Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies
- Metformin selectively affects human glioblastoma tumor-initiating cell viability
- Copper induces cellular senescence in human glioblastoma multiforme cells through downregulation of Bmi-1.
- Boron neutron capture therapy induces cell cycle arrest and cell apoptosis of glioma stem/progenitor cells in vitro
- Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies
- Identification of U251 glioma stem cells and their heterogeneous stem-like phenotypes
- Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide
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