Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
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Summary
It is shown that selective accumulation of the citric acid cycle intermediate succinate is a universal metabolic signature of ischaemia in a range of tissues and is responsible for mitochondrial ROS production during reperfusion, and a new pathway for metabolic control of ROS production in vivo is revealed.
- Type
- article
- Published
- 2014-11-05
- Cited by
- 2,631
- References
- 56
- OpenAlex
- https://openalex.org/W2122091775
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4398457
Keywords
Reactive oxygen species, Mitochondrial ROS, Reperfusion injury, Mitochondrion, Ischemia
References
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- Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness
- A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury
- Letter in response to "the role of succinate and ROS in reperfusion injury - A critical appraisal" by Andrienko et al.
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- Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF‐1&agr;/VEGF axis
- Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
- Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease
- Metabolomics analysis of gut barrier dysfunction in a trauma-hemorrhagic shock rat model
- Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest
- Microthrombus‐Targeting Micelles for Neurovascular Remodeling and Enhanced Microcirculatory Perfusion in Acute Ischemic Stroke
- COMBAT - A Prospective, Randomized Investigation of Plasma First Resuscitation for Traumatic Hemorrhage and Attenuation of Acute Coagulopathy of Trauma
- Mitochondrial ROS Metabolism: 10 Years Later
- ROS signaling and redox biology in endothelial cells
- Morphometric examination of mitochondrial ultrastructure in aging cardiomyocytes
- Sex is a ubiquitous, ancient, and inherent attribute of eukaryotic life
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- Mitochondria : a target for anticancer therapy
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