The production of reactive oxygen species by complex I.
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Summary
Comparing results from the isolated enzyme with results from intact mitochondria is compared, aiming to identify similarities and differences between them and progress towards combining them to form a single, unified picture.
- Type
- article
- Published
- 2008-10-01
- Cited by
- 305
- References
- 40
- OpenAlex
- https://openalex.org/W2009595653
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40282515
Keywords
Submitochondrial particle, Superoxide, Mitochondrion, Reactive oxygen species, NAD+ kinase
References
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- The Contribution of Mitochondrial Respiratory Complexes to the Production of Reactive Oxygen Species
- The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
- Mechanism of Toxicity in Rotenone Models of Parkinson's Disease
- Structure of the Hydrophilic Domain of Respiratory Complex I from Thermus thermophilus
- Inhibitors of the Quinone-binding Site Allow Rapid Superoxide Production from Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I)*
- Mitochondria, oxygen free radicals, disease and ageing.
- Characterization of the complex I-associated ubisemiquinone species: toward the understanding of their functional roles in the electron/proton transfer reaction.
- Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins.
- The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2
- Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.
- Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species.
- Thermodynamic analysis of flavin in mitochondrial NADH:ubiquinone oxidoreductase (complex I).
- Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.
- Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria.
- Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane.
- Generation of reactive oxygen species by the mitochondrial electron transport chain
- Consistent structure between bacterial and mitochondrial NADH:ubiquinone oxidoreductase (complex I).
Cited by
- An Src Homology 3 Domain-Like Fold Protein Forms a Ferredoxin Binding Site for the Chloroplast NADH Dehydrogenase-Like Complex in Arabidopsis[W]
- Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?
- The Effect of Cellular Stress on T and B Cell Memory Pathways in Immunized and Unimmunized BALB/c Mice
- Effect of cyclosporin A on the tumor microenvironment
- Mitochondria and reactive oxygen species. Which role in physiology and pathology?
- Abnormal Ca2+ Cycling in Failing Ventricular Myocytes: Role of NOS1-Mediated Nitroso-Redox Balance
- Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency.
- INTRA-MITOCHONDRIAL INJURY DURING ISCHEMIA-REPERFUSION
- NOVEL COMPOUNDS AS POTENTIAL ALZHEIMER'S DISEASE THERAPEUTICS AND INHIBITORS OF THE NLRP3 INFLAMMASOME
- Investigating the role of mitochondrial respiratory chain activity and mitochondrial DNA damage in skin ageing
- BIOTECHNOLOGICAL TOOLS TO STUDY TOMATO FRUIT QUALITY UNDER STRESS CONDITIONS
- Aspirin and multiple sclerosis
- iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
- Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production: a correction using glutathione depletion
- The effect of ageing on macrophage Toll‐like receptor‐mediated responses in the fight against pathogens
- Modeling the respiratory chain and the oxidative phosphorylation
- Albumin Uptake in OK Cells Exposed to Rotenone: A Model for Studying the Effects of Mitochondrial Dysfunction on Endocytosis in the Proximal Tubule?
- Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action.
- Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase.
- Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator.
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