Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19‐mediated adhesion of B cells in a PI3K‐dependent manner

Keywords

Biology, breakpoint cluster region, CD19, B cell, B-cell receptor

References

• CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplificationTod Luginbuhl — 2000
• Src Homology Region 2 Domain-Containing Phosphatase 1 Positively Regulates B Cell Receptor-Induced Apoptosis by Modulating Association of B Cell Linker Protein with Nck and Activation of c-Jun NH2-Terminal Kinase1C. S. Kramer — 2002
• Mechanisms of B cell receptor induced apoptosisPierre Ozer, Marc Salmon, Yannick Theunissen — 2004
• Targets of B‐cell antigen receptor signaling: the phosphatidylinositol 3‐kinase/Akt/glycogen synthase kinase‐3 signaling pathway and the Rap1 GTPaseMichael R. Gold, Robert J. Ingham, Sarah J. McLeod — 2000
• Activation of human B cells through the CD19 surface antigen results in homotypic adhesion by LFA-1-dependent and -independent mechanisms.Susan Smith, Kevin P. Rigley, Robin E. Callard — 1991
• Biological aspects of signal transduction by cell adhesion receptors.Suresh K. Alahari, Peter J. Reddig, R. L. Juliano — 2002
• B cell signaling. Introduction.Takeshi Tsubata, Jürgen Wienands — 2001
• The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc.AM Teixeira, J Fawcett, DL Simmons — 1994
• CD72 Down-Modulates BCR-Induced Signal Transduction and Diminishes Survival in Primary Mature B Lymphocytes1Daniel H. Li, James W. Tung, Ingo H. Tarner — 2006
• CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.Shinichi Sato, Douglas A. Steeber, Paul J. Jansen — 1997
• Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway.Geoffrey S. Kansas, Thomas F. Tedder — 1991
• Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Isoforms Alternatively Inhibit and Costimulate Human T Cell Function1Daohong Chen, Hideki Iijima, Takashi Nagaishi — 2004
• Inhibition of the MEK/ERK Signaling Pathway Blocks a Subset of B Cell Responses to Antigen1Jim Richards, Shaival H. Davé, Chih-Hao Gilbert Chou — 2001
• Differential Roles for Extracellularly Regulated Kinase-Mitogen-Activated Protein Kinase in B Cell Antigen Receptor-Induced Apoptosis and CD40-Mediated Rescue of WEHI-231 Immature B Cells1Stephen B. Gauld, Derek Blair, Catriona A. Moss — 2002
• The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation.Takahiro Adachi, Heinrich Flaswinkel, Hidetaka Yakura — 1998
• Stimulation of B lymphocytes through surface Ig receptors induces LFA-1 and ICAM-1-dependent adhesion.Lương Hữu Đăng, Kenneth L. Rock — 1991
• Extracellular signal-regulated kinase-2, but not c-Jun NH2-terminal kinase, activation correlates with surface IgM-mediated apoptosis in the WEHI 231 B cell line.Jong Ran Lee, Gary A. Koretzky — 1998
• Src Homology Region 2 (SH2) Domain-Containing Phosphatase-1 Dephosphorylates B Cell Linker Protein/SH2 Domain Leukocyte Protein of 65 kDa and Selectively Regulates c-Jun NH2-Terminal Kinase Activation in B Cells1Kazuya Mizuno, Yuko Tagawa, Katsuyuki Mitomo — 2000
• Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signalsTie Chen, Wolfgang Zimmermann, J. Brandon Parker — 2001
• CD22 Regulates B Cell Receptor-mediated Signals via Two Domains That Independently Recruit Grb2 and SHP-1*Kevin L. Otipoby, Kevin E. Draves, Edward A. Clark — 2001

Cited by

• Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseasesLing Ye, Jian Wang, Lingyan Wang — 2015
• ITAM-like signalling for efficient phagocytosis : The paradigm of the granulocyte receptor CEACAM3S. Pils — 2010
• CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signalingShuhei Hosomi, Zhangguo Chen, Kristi Baker — 2013
• Die funktionelle Bedeutung der Interaktion von löslichem CEACAM8 und CEACAM1 auf naiven B-Zellen und aktivierten LymphozytenMiriam Kellich — 2014
• Soluble CEACAM8 Interacts with CEACAM1 Inhibiting TLR2-Triggered Immune ResponsesBernhard B. Singer, Lena Opp, Annina Heinrich — 2014
• CEACAM1 Regulates Fas-mediated Apoptosis in Jurkat T-cells via its Interaction with β-cateninYun Li, John E. Shively — 2013
• Generation of Human CEACAM1 Transgenic Mice and Binding of Neisseria Opa Protein to Their NeutrophilsAngel Gu, Zhifang Zhang, Nan Zhang — 2010
• The Possible Roles of OPN-Regulated CEACAM1 Expression in Promoting the Survival of Activated T Cells and the Apoptosis of Oral Keratinocytes in Oral Lichen Planus PatientsGuixiang Liu, Qi Xie, Chengjun Zhou — 2011
• Moraxella catarrhalis Adhesin UspA1-derived Recombinant Fragment rD-7 Induces Monocyte Differentiation to CD14+CD206+ PhenotypeQi Xie, Louise S. Brackenbury, Darryl J. Hill — 2014
• Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to EstrogenHongye Fan, Guanjun Dong, Guangfeng Zhao — 2014
• Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte-colony stimulating factor receptorHao Pan, John E. Shively — 2010
• CEACAM1 induces B-cell survival and is essential for protective antiviral antibody productionVishal Khairnar, Vikas Duhan, Sathish Kumar Maney — 2015
• CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 ComplexRongze Lu, Hao Pan, John E. Shively — 2012
• CEACAM1 loss links inflammation to Insulin Resistance in obesity and Non-alcoholic Steatohepatitis (NASH)Sonia M. Najjar, Lucia Russo — 2013
• The Short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell inductionLanfen Chen, Zhangguo Chen, Kristi Baker — 2012
• Mice with null mutation of Ceacam I develop nonalcoholic steatohepatitisSonia M. Najjar — 2010
• Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasisNicole Beauchemin, Azadeh Arabzadeh — 2013
• Targeted Deletion of Murine CEACAM 1 Activates PI3K-Akt Signaling and Contributes to the Expression of (Pro)renin Receptor via CREB Family and NF-κB Transcription FactorsJiqian Huang, Kelly J. Ledford, William B. Pitkin — 2013
• Do inhibitory immune receptors play a role in the etiology of autoimmune disease?Marloes J. M. Olde Nordkamp, Bobby P. C. Koeleman, Linde Meyaard — 2014
• BCL2 Predicts Survival in Germinal Center B-cell–like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and RituximabJaveed Iqbal, Paul N. Meyer, Lynette M. Smith — 2011

Related papers

• Autoinhibition and adapter function of SykYogesh Kulathu, Gesina Grothe, Michael Reth — 2009
• Distinctive functions of Syk N-terminal and C-terminal SH2 domains in the signaling cascade elicited by oxidative stress in B cells.Jian Ding, Tomoko Takano, Patrice Hermann — 2000
• Interdomain A is crucial for ITAM-dependent and -independent regulation of Syk.Takahiro Adachi, Jürgen Wienands, Takeshi Tsubata — 2007
• SYK Inhibition Modulates Distinct PI3K/AKT-dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B-cell LymphomasLin‐Feng Chen, Stefano Monti, Przemysław Juszczyński — 2013
• CD 19 function in central and peripheral B-cell developmentChristopher J. Del Nagro, Dennis C. Otero, Amy N. Anzelon — 2005
• SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma.Lin‐Feng Chen, Stefano Monti, Przemysław Juszczyński — 2008
• Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cellsXiaocui He, Kathrin Kläsener, Joseena Iype — 2018
• CD19 differentially regulates BCR signalling through the recruitment of PI3KYuekang Xu, Kirsten A. Fairfax, Amanda Light — 2014
• The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts.Anu Cherukuri, Paul C. Cheng, Hae Won Sohn — 2001
• CD19, from bench to bedside.Xinchen Li, Ying Ding, Mengting Zi — 2017