Targeted Deletion of Murine CEACAM 1 Activates PI3K-Akt Signaling and Contributes to the Expression of (Pro)renin Receptor via CREB Family and NF-κB Transcription Factors
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Summary
Global null deletion of Ceacam1 caused an increase in blood pressure with increased renin-angiotensin system activation together with upregulation of PRR via PI3K-Akt activation of cAMP response element–binding protein 1, ATF-1, ATF -2, and NF-&kgr;B p65 transcription factors.
- Type
- article
- Published
- 2013-06-03
- Cited by
- 33
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2106961171
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14111335
Keywords
Protein kinase B, Endocrinology, PI3K/AKT/mTOR pathway, Downregulation and upregulation, Internal medicine
References
- Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials.
- Renal (pro)renin receptor contributes to development of diabetic kidney disease through TGFβ1-CTGF signaling cascade
- Animal models and programming of the metabolic syndrome.
- Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.
- CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.
- Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.
- Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus
- Cyclic adenosine 3',5'-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.
- CREB Mediates UTP-Directed Arterial Smooth Muscle Cell Migration and Expression of the Chemotactic Protein Osteopontin via Its Interaction with Activator Protein-1 Sites
- Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
- Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance.
- The association of hypertension and diabetes: prevalence, cardiovascular risk and protection by blood pressure reduction
- Extracellular Signals Regulate Rapid Coactivator Recruitment at AP-1 Sites by Altered Phosphorylation of both CREB Binding Protein and c-jun
- (Pro)renin Receptor Contributes to Diabetic Nephropathy Through Enhancing Renal Inflammation
- American College of Endocrinology position statement on the insulin resistance syndrome.
- Rodent Models for Metabolic Syndrome Research
- Effect of inhibition of the renin-angiotensin system on development of type 2 diabetes mellitus (meta-analysis of randomized trials).
- Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.
- The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.
- Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen.
Cited by
- Interaction of the renin angiotensin and cox systems in the kidney
- Pregnancy-specific glycoproteins: complex gene families regulating maternal-fetal interactions.
- High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion.
- Colocalization of the (Pro)renin Receptor/Atp6ap2 with H+-ATPases in Mouse Kidney but Prorenin Does Not Acutely Regulate Intercalated Cell H+-ATPase Activity
- Role of the Collecting Duct Renin Angiotensin System in Regulation of Blood Pressure and Renal Function
- Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport.
- Effects of Cardiotonic Steroids and Insulin on Sodium Pump Signaling
- The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis
- CEACAM1 as a multi-purpose target for cancer immunotherapy
- How is the Brain Renin-Angiotensin System Regulated?
- Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
- Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene
- Nicotinamide Mononucleotide in the Context of Elevated Plasma Levels of Free Fatty Acids Improves Glucose Tolerance by Decreasing Insulin Clearance
- The (pro)renin receptor – An emerging player in hypertension and metabolic syndrome
- Hepatic Insulin Clearance: Mechanism and Physiology.
- Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells
- Ghrelin-Induced Sodium Reabsorption Is Mediated by PKA and Microtubule-Dependent αENaC Translocation in Female Rats
- Dietary substitution of SFA with MUFA within high-fat diets attenuates hyperinsulinaemia and pancreatic islet dysfunction
- The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule
- Insulin Resistance Is Cheerfully Hitched with Hypertension
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