CpG motifs in bacterial DNA and their immune effects.
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Summary
Oligodeoxynucleotides containing CpG ODN enhance the development of acquired immune responses for prophylactic and therapeutic vaccination and protect against lethal challenge with a wide variety of pathogens.
- Type
- review
- Published
- 2002-04-01
- Cited by
- 2,771
- References
- 294
- OpenAlex
- https://openalex.org/W2118011548
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25331583
Keywords
Biology, Innate immune system, CpG site, CpG Oligodeoxynucleotide, TLR9
References
- Synthetic Oligonucleotides with Certain Palindromes Stimulate Interferon Production of Human Peripheral Blood Lymphocytes in vitro
- Characterization and Modulation of Immune Stimulation by Modified Oligonucleotides
- Immunostimulatory oligodeoxynucleotide induces TH1 immune response and inhibition of IgE antibody production to cedar pollen allergens in mice.
- High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice
- CpG Oligonucleotides Are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T Cells In Vivo
- Repeated Administration of Cytosine-Phosphorothiolated Guanine-Containing Oligonucleotides Together with Peptide/Protein Immunization Results in Enhanced CTL Responses with Anti-Tumor Activity1
- Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice
- Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor.
- Stage-specific oligonucleotide uptake in murine bone marrow B-cell precursors.
- Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype.
- Oligodeoxynucleotides Enhance Lipopolysaccharide-Stimulated Synthesis of Tumor Necrosis Factor: Dependence on Phosphorothioate Modification and Reversal by Heparin
- Evaluation of the protective efficacy of a rabies DNA vaccine in mice using an intracerebral challenge model.
- The immunologic properties of DNA.
- How BCG led to the discovery of immunostimulatory DNA.
- Comparison of Cellular Binding and Uptake of Antisense Phosphodiester, Phosphorothioate, and Mixed Phosphorothioate and Methylphosphonate Oligonucleotides
- Characterization of the nuclear binding sites of oligodeoxyribonucleotides and their analogs.
- Cationic lipid:bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models.
- A Targeted DNA Vaccine Augments the Natural Immune Response to Self TNF-α and Suppresses Ongoing Adjuvant Arthritis1
- Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides.
- Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.
Cited by
- CpG Still Rocks! Update on an Accidental Drug
- Spermine Protects Mice Against Lethal Sepsis Partly by Attenuating Surrogate Inflammatory Markers
- Regulation of memory CD8 T cell differentiation
- Novel vaccines protecting against the development of allergic disorders: a double-edged sword?
- Making and breaking tolerance.
- Identification of a sequence from the genome of porcine circovirus type 2 with an inhibitory effect on IFN-alpha production by porcine PBMCs.
- NF-kappaB- and c-Jun-dependent regulation of human cytomegalovirus immediate-early gene enhancer/promoter in response to lipopolysaccharide and bacterial CpG-oligodeoxynucleotides in macrophage cell line RAW 264.7.
- Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner
- Co-administration of CpG oligonucleotides enhances the late affinity maturation process of human anti-hepatitis B vaccine response.
- 3,3',5'-Triiodo-L-Thyronine Reduces Efficiency of mRNA Knockdown by Antisense Oligodeoxynucleotides: A Study with Pyroglutamyl Aminopeptidase II in Adenohypophysis
- Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
- Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors1
- Epigenetic manipulation of gene expression
- Detection and identification of bacterial DNA in serum from patients with acute pancreatitis
- Changes in Immune Responses to Antigen Applied to Tape-Stripped Skin with CpG-Oligodeoxynucleotide in NC/Nga Mice
- A Selective Role for the TNF p55 Receptor in Autocrine Signaling following IFN-γ Stimulation in Experimental Autoimmune Uveoretinitis1
- Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.
- Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex.
- Synergism between CpG-Containing Oligodeoxynucleotides and IL-2 Causes Dramatic Enhancement of Vaccine-Elicited CD8+ T Cell Responses1
- Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes.
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