Synergy of CpG oligodeoxynucleotide and double-stranded RNA (poly I:C) on nitric oxide induction in chicken peripheral blood monocytes.
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Summary
The results show that a combination of bacterial DNA and dsRNA induces an enhanced inflammatory immune response that has both antiviral and antibacterial activity in primary chicken monocytes.
- Type
- article
- Published
- 2007-05-01
- Cited by
- 102
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W17339052
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40343177
Keywords
Quadtree, Cartesian coordinate system, Euler's formula, Euler equations, Regular grid
References
- Nitric oxide and the immune response
- Identification and Functional Characterization of Chicken Toll-Like Receptor 5 Reveals a Fundamental Role in the Biology of Infection with Salmonella enterica Serovar Typhimurium
- Nitric oxide in neurodegeneration.
- A Toll-like receptor recognizes bacterial DNA
- TIRAP: an adapter molecule in the Toll signaling pathway
- APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA
- Toll-like receptors: critical proteins linking innate and acquired immunity
- Oxidative burst mediated by toll like receptors (TLR) and CD14 on avian heterophils stimulated with bacterial toll agonists.
- Effect of double-stranded RNA and interferon on the antiviral activity of Atlantic salmon cells against infectious salmon anemia virus and infectious pancreatic necrosis virus.
- Inducible nitric oxide synthase and control of intracellular bacterial pathogens.
- Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR*
- Role of protein kinase R in double‐stranded RNA‐induced expression of nitric oxide synthase in human astroglia
- Small molecule inhibitors of the RNA-dependent protein kinase.
- Toll-like receptors: emerging targets of immunomodulation
- Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.
- Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
- In-silico identification of chicken immune-related genes
- In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in neonatal chickens by immunostimulatory CpG oligodeoxynucleotide.
- Immunotherapeutic uses of CpG oligodeoxynucleotides
- Heterophil cytokine mRNA profiles from genetically distinct lines of chickens with differential heterophil-mediated innate immune responses
Cited by
- Biodegradable nanoparticles containing TLR3 or TLR9 agonists together with antigen enhance MHC-restricted presentation of the antigen
- Toll-like receptor (TLR)21 signalling-mediated antiviral response against avian influenza virus infection correlates with macrophage recruitment and nitric oxide production.
- A Toll-like receptor 3 agonist (polyI:C) elicits innate host responses in the spleen and lungs of chickens.
- Immunostimulatory effects and delivery of oligodeoxynucleotides containing CpG motifs (CpG-ODN) in neonatal broiler chickens
- Molecular genetic assessment of chicken macrophage innate immunity: toll-like receptors, mechanisms of action, and kinetic transcriptome profile
- Effects of Ligands for Toll-Like Receptors 3, 4, and 21 as Adjuvants on the Immunogenicity of an Avian Influenza Vaccine in Chickens
- Recombinant flagellin and its cross-talk with lipopolysaccharide--effect on pooled chicken peripheral blood mononuclear cells.
- CpG oligodeoxynucleotide and double-stranded RNA synergize to enhance nitric oxide production and mRNA expression of inducible nitric oxide synthase, pro-inflammatory cytokines and chemokines in chicken monocytes
- Phosphorothioate oligodeoxyribonucleotides induce in vitro proliferation of chicken B-cells.
- Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides.
- Avian toll-like receptors
- Immunostimulatory properties of Toll-like receptor ligands in chickens.
- Mannose Receptor Ligands Regulate the Gene Expression of Toll-like Receptors in Chicken Monocytes
- Double-stranded RNA- and CpG DNA-induced immune responses in Atlantic salmon: comparison and synergies.
- Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands.
- Bursal transcriptome of chickens protected by DNA vaccination versus those challenged with infectious bursal disease virus
- Co-stimulation with TLR3 and TLR21 ligands synergistically up-regulates Th1-cytokine IFN-γ and regulatory cytokine IL-10 expression in chicken monocytes.
- A Critical Role for MAPK Signalling Pathways in the Transcriptional Regulation of Toll Like Receptors
- Immunotherapeutic Potential of CpG Oligonucleotides in Chickens
- Induction of innate host responses in the lungs of chickens following infection with a very virulent strain of Marek's disease virus.
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