The regulation and function of c-fos and other immediate early genes in the nervous system.
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Summary
This review highlights the importance of identifying the genes that are responsive to trans-synaptic stimulation and membrane electrical activity in neural cells and proposes that IEGs encode regulatory proteins that control the expression of late response genes.
- Type
- review
- Published
- 1990-04-01
- Cited by
- 2,383
- References
- 114
- OpenAlex
- https://openalex.org/W2115736681
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7660874
Keywords
Function (biology), Neuroscience, Gene, Nervous system, Biology
References
- A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence
- c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.
- Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors.
- The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.
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- Leucine zipper structure of the protein CRE‐BP1 binding to the cyclic AMP response element in brain.
- Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.
- Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
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- Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP.
- Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.
- Complexity of the early genetic response to growth factors in mouse fibroblasts
- Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro
- fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen
- Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells.
- The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: genomic structure and expression in rat brain after seizure induction
- In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
- Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression
- Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells
- Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
Cited by
- Acute lithium treatment enhances neuropeptide Y gene expression in rat hippocampus.
- Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity.
- Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model.
- Differential effects of reserpine on brainstem catecholaminergic neurons revealed by Fos protein immunohistochemistry.
- Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus.
- Calcium transients in brain ischemia: role in neuronal injury.
- Ontogeny of Sex Differences in the Mammalian Hypothalamus and Preoptic Area
- Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus.
- Fos protein immunoreactivity in the developing olfactory bulbs of normal and naris-occluded rats.
- Early functional neural networks in the developing retina
- Expression and signal transduction pathways of gonadotropin-releasing hormone receptors.
- c-fos mRNA in the suprachiasmatic nuclei in vitro shows a circadian rhythm and responds to a serotonergic agonist.
- Time course, localization and pharmacological modulation of immediate early inducible genes, brain-derived neurotrophic factor and trkB messenger RNAs in the rat brain following photochemical stroke.
- Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
- Hypercapnia induces c-fos expression in neurons of retrotrapezoid nucleus in cats.
- Differential expression of immediate‐early proteins in non‐nerve cells after focal brain injury
- Fos expression induced by changes in arterial pressure is localized in distinct, longitudinally organized columns of neurons in the rat midbrain periaqueductal gray
- In vivo antisense approaches to the role of immediate early gene expression in the brain.
- jun-B gene expression in rat retinal cells following focal retinal injury.
- Pontine cholinergic neurons show Fos-like immunoreactivity associated with cholinergically induced REM sleep.
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