Direct effect of glucocorticoids on lipolysis in adipocytes.
Explore this paper's citation graph
Summary
It is shown that elevated FFA concentration in plasma is associated with increased lipase activity and lipolysis in vivo in adipose tissues of dexamethasone-treated rats, which could be a cellular basis of systemic FFA elevation in response to glucocorticoid challenge.
- Type
- article
- Published
- 2009-07-01
- Cited by
- 298
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2115274616
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25089951
Keywords
Lipolysis, Adipose triglyceride lipase, Perilipin, Internal medicine, Endocrinology
References
- Effect of growth hormone and dexamethasone on lipolysis and metabolism in isolated fat cells of the rat.
- Degradation of perilipin is mediated through ubiquitination-proteasome pathway.
- Effects of Glucocorticoids on Metabolism of Adipose Tissue in Vitro
- cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior.
- Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue.
- An effect of insulin on cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in fat cells.
- Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.
- Effects of changes in serum insulin in response to dexamethasone and adrenalectomy on insulin-sensitive phosphodiesterase in rat fat cells.
- Regulation and function of triacylglycerol lipases in cellular metabolism.
- Insulin resistance in type 2 diabetes: role of fatty acids
- Role of PAT proteins in lipid metabolism.
- Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids.
- Desnutrin, an Adipocyte Gene Encoding a Novel Patatin Domain-containing Protein, Is Induced by Fasting and Glucocorticoids
- Translocation of Hormone-sensitive Lipase and Perilipin upon Lipolytic Stimulation of Rat Adipocytes*
- Glucocorticoid hormone binding to human adipose tissue
- Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes.
- Permissive action of glucocorticoids on catecholamine-induced lipolysis: direct "in vitro" effects on the fat cell beta-adrenoreceptor-coupled-adenylate cyclase system.
- The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets.
- Mapping of Early Signaling Events in Tumor Necrosis Factor-α-mediated Lipolysis in Human Fat Cells*
- Effect of dexamethasone on adenosine 3',5'-monophosphate content and phosphodiesterase activities in 3T3-L1 adipocytes.
Cited by
- Adipogenic and lipolytic effects of chronic glucocorticoid exposure.
- Acute Up-Regulation of Adipose Triglyceride Lipase and Release of Non-Esterified Fatty Acids by Dexamethasone in Chicken Adipose Tissue
- Dexamethasone Reduces Energy Expenditure And Increases Susceptibility To Diet-Induced Obesity In Mice
- Endocannabinoids: Effectors of glucocorticoid signaling.
- Stress et prise alimentaire : Application à l'étude de l'effet anti-stress d'un extrait de levure chez le rat
- Bioinformatics Software and Methods for Genome-wide Association and ChIP-Seq Studies.
- REGULATION OF LIPID METABOLISM AND MILK LIPID CONTENT IN NORTHERN ELEPHANT SEALS
- The Role of Systemic Inflammation in the Development of Equine Laminitis
- Glucocorticoids and Metabolic Control.
- How Do Glucocorticoids Regulate Lipid Metabolism?
- Diseases of New World Camelids
- Physiological functions of the adrenocortical circadian clock
- Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess.
- Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
- Spontaneous hypertension occurs with adipose tissue dysfunction in perilipin-1 null mice.
- Transcriptomic analysis of skeletal muscle from beef cattle exposed to illicit schedules containing dexamethasone: identification of new candidate biomarkers and their validation using samples from a field monitoring trial
- The glucocorticoid contribution to obesity
- Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes.
- General Theory of Body Contouring: 1. Processes of Quick and Slow Modulation of Subcutaneous Fat Tissue
- Several agents and pathways regulate lipolysis in adipocytes.
Related papers
- Control of Lipolysis by Perilipins
- Abstract 18236: Perilipin 5 Links Lipid Droplets with Mitochondria
- Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization
- Hormone‐sensitive lipase preferentially redistributes to lipid droplets associated with perilipin‐5 in human skeletal muscle during moderate‐intensity exercise
- Physiological Relevance Of Lipid Droplet And Lipid-associated Protein During Lipolytic Activation In Adipocytes: 2122
- Crucial role of CGI-58/alpha/beta hydrolase domain-containing protein 5 in lipid metabolism.
- Cardiotrophin-1 stimulates lipolysis through the regulation of main adipose tissue lipases[S]