Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
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Summary
The results suggest that maternal dietary betaine supplementation during gestation attenuates hepatic lipogenesis in neonatal piglets via epigenetic and GR-mediated mechanisms.
- Type
- article
- Published
- 2016-01-01
- Cited by
- 40
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1824236738
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9022542
Keywords
Glucocorticoid receptor, Endocrinology, Betaine, Biology, Lipogenesis
References
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- Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats
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- Role of glucocorticoids in the regulation of lipogenesis
- Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator–activated receptor γ coactivator 1α promoter
- Cortisol and 17-Hydroxyprogesterone Levels in Saliva of Healthy Neonates
- Genome-Wide Analysis of Glucocorticoid Receptor Binding Regions in Adipocytes Reveal Gene Network Involved in Triglyceride Homeostasis
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
- Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7α1 in the liver of weaning piglets.
- Associations between liver histology and cortisol secretion in subjects with nonalcoholic fatty liver disease
- MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain.
- Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects.
- Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
- The functions of animal microRNAs
- Maternal dietary protein affects transcriptional regulation of myostatin gene distinctively at weaning and finishing stages in skeletal muscle of Meishan pigs
- Minireview: Stress-related psychiatric disorders with low cortisol levels: a metabolic hypothesis.
- Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin
- Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet
Cited by
- Expression of hepatic miRNAs targeting porcine glucocorticoid receptor (GR) 3′UTR in the neonatal piglets under a maternal gestational betaine supplementation
- Methionine restriction on lipid metabolism and its possible mechanisms
- Dysregulation of Placental miRNA in Maternal Obesity Is Associated With Pre- and Postnatal Growth
- Tasks of some dietary essential nutrients on epigenetics and one carbon metabolism in livestock during production
- In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications
- Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and -independent pathways
- Enhanced adipogenesis in Mashen pigs compared with Large White pigs
- Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.
- Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig
- Dietary betaine supplementation increases adrenal expression of steroidogenic acute regulatory protein and yolk deposition of corticosterone in laying hens
- Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
- Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression
- Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.
- Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.
- Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation
- Maternal high-protein diet modulates hepatic growth axis in weaning piglets by reprogramming the IGFBP-3 gene
- Maternal betaine suppresses adrenal expression of cholesterol trafficking genes and decreases plasma corticosterone concentration in offspring pullets
- [Research advances in the association between maternal intake of methyl donor nutrients during pregnancy and DNA methylation in offspring].
- PENGARUH PENAMBAHAN TEPUNG KUNYIT DAN BETAIN PADA RANSUM TERHADAP BERAT KARKAS, TEBAL LEMAK PUNGGUNG DAN LOIN EYE AREA BABI FINISHER (Effect of Dietary Turmeric Flour and Betain Addition on Carcass Weight, Backfat Thickness and Loin Eye Area of Finisher Pig)
- The Effects of Maternal and Postnatal Dietary Methyl Nutrients on Epigenetic Changes that Lead to Non-Communicable Diseases in Adulthood
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