Mitochondria and apoptosis.
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Summary
A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
- Type
- review
- Published
- 1998-08-28
- Cited by
- 5,380
- References
- 46
- OpenAlex
- https://openalex.org/W2113999599
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40807877
Keywords
Mitochondrion, Apoptosis, Cell biology, Cytochrome c, Bcl-2 family
References
- Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors.
- Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.
- Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.
- Cell death: the significance of apoptosis.
- Intracellular ATP levels determine cell death fate by apoptosis or necrosis.
- Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
- X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
- The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
- Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
- Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
- The effect of lethal doses of x-irradiation on the enzymatic activity of mitochondrial cytochrome c.
- Toward the molecular structure of the mitochondrial channel, VDAC
- Archaeal-eubacterial mergers in the origin of Eukarya: phylogenetic classification of life.
- Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.
- Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution
- Bcl‐2 Protects Neural Cells from Cyanide/Aglycemia‐Induced Lipid Oxidation, Mitochondrial Injury, and Loss of Viability
- Bcl-xL forms an ion channel in synthetic lipid membranes
- Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide‐induced apoptosis
- The Mitochondrial F0F1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells.
- Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
Cited by
- Sepsis-induced erythrocytes apoptosis
- A concomitant ATP-depleting strategy markedly enhances anticancer agent activity
- Mast cell apoptosis and survival.
- Calcium signaling in mast cells: focusing on L-type calcium channels.
- Role of mitochondria in alcoholic liver injury.
- The Roles of Reelin, Bcl2, and Serotonin in Cerebellar Pathology in Autism
- Airway epithelium and apoptosis
- Hypothalamic digoxin and regulation of body mass index.
- Targeted Photodynamic Therapy Agent with a Built-In Apoptosis Sensor for in Vivo Near-Infrared Imaging of Tumor Apoptosis Triggered by its Photosensitization in Situ
- Gastrointestinal tumours: let there be light.
- FK506 prevents stroke-induced generation of ceramide and apoptosis signaling.
- Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases.
- Neurons undergo apoptosis in animal and cell culture models of diabetes.
- Mitochondrial Disorders. A Diagnostic Challenge in Clinical Chemistry
- The mitochondrion in cell death control: certainties and incognita.
- Temperature-dependent Arrest of Neutrophil Apoptosis
- dFADD, a Novel Death Domain-containing Adapter Protein for theDrosophila Caspase DREDD*
- Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia.
- Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator
- High‐throughput profiling of the mitochondrial proteome using affinity fractionation and automation
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