Optimizing adjuvant endocrine therapy in postmenopausal women with early-stage breast cancer: a decision analysis.
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Summary
Modeling estimates suggest that sequential adjuvant therapy with tamoxifen followed by an aromatase inhibitor after 2.5 years yields improved outcomes compared with either drug alone or cross-over treatment after 5 years of tamoxIFen.
- Type
- article
- Published
- 2005-08-01
- Cited by
- 100
- References
- 17
- Access
- Open access
- OpenAlex
- https://openalex.org/W2111759050
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44705023
Keywords
Aromatase inhibitor, Tamoxifen, Medicine, Aromatase, Breast cancer
References
- National Institutes of Health Consensus Development Conference Statement: adjuvant therapy for breast cancer, November 1-3, 2000.
- Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early‐stage breast cancer
- Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial.
- Prognosis following salvage mastectomy for recurrence in the breast after conservative surgery and radiation therapy for early-stage breast cancer.
- Annual hazard rates of recurrence for breast cancer after primary therapy.
- Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response.
- Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
- Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer.
- P81 Benefits of switching postmenopausal women withhormone-sensitive early breast cancer to anastrozole after 2 years adjuvant tamoxifen: combined results from 3123 women enrolled in the ABCSG Trial 8 and the ARNO 95 Trial
- A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.
- Switching to exemestane after 2-3 years of adjuvant tamoxifen prolongs disease-free survival, but not overall survival, in postmenopausal women surviving primary breast cancer, compared with continuous tamoxifen.
- Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.
- Markov Models in Medical Decision Making
- BIG 1-98: Randomized double-blind phase III study to evaluate letrozole (L) vs. tamoxifen (T) as adjuvant endocrine therapy for postmenopausal women with receptor-positive breast cancer
- Aromatase inhibitors: rationale for use following antiestrogen therapy.
- Anastozole (A) is superior to tamoxifen (T) in treatment of postmenopausal (PM) women with early breast cancer (EBC) - First results of the ATAC (Arimidex, tamoxifen, alone or in combination) trial (on behalf of the ATAC Trialists' Group)
- Switching to exemestane after 2–3 years of adjuvant tamoxifen prolongs disease-free survival, but not overall survival, in postmenopausal women surviving primary breast cancer, compared with continuous tamoxifen☆, ☆, ☆☆☆Abstracted from: Coombes RC, Hall E, Gibson LJ, et al. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med 2004;350:1081–92.
Cited by
- Aromatase Inhibitors in Early Hormone Receptor-Positive Breast Cancer
- Adjuvant hormonal therapy in peri- and postmenopausal breast cancer.
- Adjuvant hormonal therapy for early-stage breast cancer.
- Update in medical oncology for older patients: focus on breast cancer: management of early breast cancer.
- Endocrine Therapy with Selective Estrogen Receptor Modulators (SERMs) and Aromatase Inhibitors in the Prevention and Adjuvant Therapy Settings.
- Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women
- Tamoxifen‐loaded liposomal topical formulation arrests hair growth in mice
- Prognostic factors of early distant recurrence in hormone receptor‐positive, postmenopausal breast cancer patients receiving adjuvant tamoxifen therapy
- Aromatase Inhibitors: Changing the Face of Endocrine Therapy for Breast Cancer
- Cost-effectiveness of extended adjuvant letrozole therapy after 5 years of adjuvant tamoxifen therapy in postmenopausal women with early-stage breast cancer.
- [Adjuvant endocrine therapy in postmenopausal hormone-sensitive breast cancer: to start, to switch or to extend?].
- Switching to aromatase inhibitors in early breast cancer.
- Inappropriate ATAC on tamoxifen.
- Is oral metronomic cyclophosphamide (CTX) an effective palliative treatment for patients with metastatic breast carcinoma (ABC)? experience from a retrospective series of patients
- CYP2D6 polymorphisms and the impact on tamoxifen therapy.
- Patterns and predictors of early recurrence in postmenopausal women with estrogen receptor-positive early breast cancer
- Facilitating Breast-Conserving Surgery and Preventing Recurrence: Aromatase Inhibitors in the Neoadjuvant and Adjuvant Settings
- Adjuvant therapy for postmenopausal ER-positive breast cancer. Why tamoxifen still has a future? The Leuven point of view.
- Adjuvant cyclic Tamoxifen and Megestrol acetate treatment in postmenopausal breast cancer patients--longterm follow-up.
- Letrozole Therapy Alone or in Sequence with Tamoxifen in Women with Breast Cancer
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