Inhibition of DNA methylation and reactivation of silenced genes by zebularine.
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Summary
Zebularine is a stable DNA demethylating agent and the first drug in its class able to reactivate an epigenetically silenced gene by oral administration.
- Type
- article
- Published
- 2003-03-05
- Cited by
- 545
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2111041465
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14895541
Keywords
Demethylating agent, Methylation, DNA methylation, Molecular biology, Biology
References
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- The fundamental role of epigenetic events in cancer
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- Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines.
- The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines.
- Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA.
- Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching.
- Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.
- The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor.
- Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients.
- Metabolism and effects of 5-(beta-D-ribofuranosyl)isocytosine in P815 cells.
- Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.
- Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE).
- Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone.
- Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment
- dim‐2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora
- Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine.
- Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
- Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine.
Cited by
- Drug reactivates genes to inhibit cancer.
- Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
- Epigenomics and ovarian carcinoma
- The pituitary tumour epigenome: aberrations and prospects for targeted therapy
- [Epigenetic regulation of secondary metabolite biosynthesis in filamentous fungi: a review].
- Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells
- A higher degree of expression of DNA methyl transferase 1 in cervical cancer is associated with poor survival outcome
- The relationship between DNA methylation and Reprimo gene expression in gastric cancer cells
- Epigenetic targeting therapies to overcome chemotherapy resistance.
- The epigenetic regulation of the EGF-receptor ligands Amphiregulin and Epiregulin and its impact on the outcome of EGFR-targeted therapies
- Epigenetic transcriptional repression of tumor suppresor genes and its reversion by drugs.
- Global DNA methylation analysis using methyl-sensitive amplification polymorphism (MSAP).
- Epigenetic-Based Therapies in Cancer
- Epigenetic aberrations in cholangiocarcinoma: potential biomarkers and promising target for novel therapeutic strategies.
- Use of hypomethylating agents in myelodysplastic syndromes.
- Unraveling functions of the Arabidopsis histone deacetylase HDA6 in RNA-mediated silencing, DNA damage response and plant development
- DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets.
- Epigenetic Silencing is a Novel Mechanism Controlling Cancer-Induced Pain
- Isolation and characterisation of colon cancer stem cells and the effects of epigenetic modulation on pluripotent markers
- Epigenetic regulation of tumor angiogenesis
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