Revealing the architecture of gene regulation: the promise of eQTL studies
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Summary
A combination of eQTL studies with results from traditional linkage or association studies of human disease may help predict a specific regulatory role for polymorphic sites previously associated with disease.
- Type
- review
- Published
- 2008-07-01
- Cited by
- 548
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W2110614590
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10819169
Keywords
Expression quantitative trait loci, Biology, Quantitative trait locus, Genetic architecture, Genetics
References
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- Microsatellite Instability Generates Diversity in Brain and Sociobehavioral Traits
- Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila
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- A common variant on chromosome 9p21 affects the risk of myocardial infarction.
- Expression genetics and the phenotype revolution
- Natural selection on gene expression.
- Genomic Control for Association Studies
- Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
- Genetics and analysis of quantitative traits
- The evolutionary significance of cis-regulatory mutations
- Relative impact of nucleotide and copy number variation on gene expression phenotypes
- A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity
- Genetic analysis of the mouse brain proteome
Cited by
- Serious limitations of the QTL/Microarray approach for QTL gene discovery
- Transcriptomics of salinity tolerance capacity in Arctic charr (Salvelinus alpinus): a comparison of gene expression profiles between divergent QTL genotypes.
- Fast eQTL Analysis for Twin Studies
- Buffering of Genetic Regulatory Networks in Drosophila melanogaster
- A network-driven approach for genome-wide association mapping
- Quantitative trait loci from identification to exploitation for crop improvement
- Causal stability ranking
- Genetic and Environmental Constraints on Developmental Systems: Towards Predicting Genetic Responses to Climate Change in Sea Urchins
- The molecular genetics of insulin secretion and signalling
- Études de réseaux d’expression génique : utilité pour l’élucidation des déterminants génétiques des traits complexes
- Linkage disequilibrium based eQTL analysis and comparative evolutionary epigenetic regulation of gene transcription
- Study of differential allelic expression in the breast cancer intermediate-risk susceptibility genes CHEK2, ATM and TP53
- Bioinformatics for Omics Data
- Analysis of the Aspergillus nidulans transcriptome using high-throughput RNA sequencing
- Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
- Design and analysis of genetical genomics studies and their potential applications in livestock research
- Novel Coronary Atherothrombosis Genes Identified By Blood Cell Transcriptomics
- Genetic determinants of EBV infection in lymphoblastoid cell lines
- Cross-phenotype meta-analysis reveals large-scale trans-eQTLs mediating patterns of transcriptional co-regulation
- Genetical genomics for evolutionary studies.
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