Fast eQTL Analysis for Twin Studies
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Summary
This paper randomly split twin pairs into two groups, so that within each group the samples are unrelated, and then applies a multiple linear regression analysis separately to each group, and constructs a score statistic that automatically adjusts the (hidden) correlation between the two groups.
- Type
- article
- Published
- 2015-04-10
- Cited by
- 4
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W25865703
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8838740
Keywords
Philosophy
References
- THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY
- Precision mapping of quantitative trait loci.
- Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study.
- Accurate Discovery of Expression Quantitative Trait Loci Under Confounding From Spurious and Genuine Regulatory Hotspots
- Statistical Inference in Mixed Models and Analysis of Twin and Family Data
- Computational tools for discovery and interpretation of expression quantitative trait loci
- Methodology for Genetic Studies of Twins and Families
- Meta-analysis of genome-wide association studies with overlapping subjects.
- High-Resolution Mapping of Gene Expression Using Association in an Outbred Mouse Stock
- A review of statistical methods for expression quantitative trait loci mapping
- The association between fat and lean mass and bone mineral density: the Healthy Twin Study.
- Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2
- Fitting genetic models with LISREL: Hypothesis testing
- Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS
- Classical twin studies and beyond
- An Efficient Resampling Method for Assessing Genome-Wide Statistical Significance in Mapping Quantitative Trait Loci
- Expression Quantitative Trait Loci Mapping With Multivariate Sparse Partial Least Squares Regression
- Mapping the Genetic Architecture of Gene Expression in Human Liver
- A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies
- Mapping genetic influences on ventricular structure in twins
Cited by
- Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.
- Identification of expression quantitative trait loci (eQTLs) in human peripheral blood mononuclear cells (PBMCs) and shared with liver and brain
- A Genome-Wide Integrative Association Study of DNA Methylation and Gene Expression Data and Later Life Cognitive Functioning in Monozygotic Twins
- TwinEQTL: Ultra Fast and Powerful Association Analysis for eQTL and GWAS in Twin Studies
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