Concise Review: Ex Vivo Expansion of Cord Blood‐Derived Hematopoietic Stem and Progenitor Cells: Basic Principles, Experimental Approaches, and Impact in Regenerative Medicine
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Summary
Ex vivo expansion of human HSCs/HPCs will surely have a positive impact in regenerative medicine and bring new alternatives for the treatment of neural, metabolic, orthopedic, cardiac, and neoplastic disorders.
- Type
- review
- Published
- 2013-10-07
- Cited by
- 82
- References
- 117
- Access
- Open access
- OpenAlex
- https://openalex.org/W2106265892
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:207534766
Keywords
Progenitor cell, Regenerative medicine, Haematopoiesis, Stem cell, Ex vivo
References
- Co-culture of cord blood CD34(+) cells with human BM mesenchymal stromal cells enhances short-term engraftment of cord blood cells in NOD/SCID mice.
- Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation.
- Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay.
- Cocultivation of umbilical cord blood CD34+ cells with retro-transduced hMSCs leads to effective amplification of long-term culture-initiating cells.
- Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood.
- Direct comparison by limiting dilution analysis of long-term culture-initiating cells in human bone marrow, umbilical cord blood, and blood stem cells.
- Mesenchymal stem／progenitor cells in human umbilical cord blood as support for ex vivo expansion of CD34^＋ hematopoietic stem cells and for chondrogenic differentiation
- Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
- Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors.
- Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
- Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.
- Bone marrow cells regenerate infarcted myocardium
- Comparative in vitro analysis of different hematopoietic cell populations from human cord blood: in search of the best option for clinically oriented ex vivo cell expansion
- Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells.
- Notch signaling: control of cell communication and cell fate
- Ex vivo Expansion of Umbilical Cord Blood Stem Cells Using Different Combinations of Cytokines and Stromal Cells
- Hematopoietic Stem Cells Are Pluripotent and Not Just “Hematopoietic”
- Umbilical cord blood: lessons learned and lingering challenges after more than 20 years of basic and clinical research.
- From marrow to brain: expression of neuronal phenotypes in adult mice.
- Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion.
Cited by
- Characterization of Blood-Derived Human Progenitor Cells for Vascular Regeneration
- Cord blood clinical processing, cryopreservation, and storage.
- Islet Regenerative Properties of Ex Vivo Expanded Hematopoietic Progenitor Cells
- Umbilical cord blood transplantation supplemented with the infusion of mesenchymal stem cell for an adolescent patient with severe aplastic anemia: a case report and review of literature
- Mitochondrial superoxide reduction and cytokine secretion skewing by carbon nanotube scaffolds enhance ex vivo expansion of human cord blood hematopoietic progenitors.
- Nuevos estándares internacionales para terapia celular y trasplante de células de sangre de cordón umbilical
- Hematopoietic Support Capacity of Mesenchymal Stem Cells: Biology and Clinical Potential.
- Immobilisation of a thrombopoietin peptidic mimic by self-assembled monolayers for culture of CD34+ cells.
- Inhibiting HDAC for human hematopoietic stem cell expansion.
- Bioengineering a Human Plasma‐Based Epidermal Substitute With Efficient Grafting Capacity and High Content in Clonogenic Cells
- Differential ability of MSCs isolated from placenta and cord as feeders for supporting ex vivo expansion of umbilical cord blood derived CD34+ cells
- Developmental Maturation within the Hematopoietic System
- Stem cell therapy for amyotrophic lateral sclerosis
- Large scale industrialized cell expansion: producing the critical raw material for biofabrication processes
- Expanded Hematopoietic Progenitor Cells Reselected for High Aldehyde Dehydrogenase Activity Demonstrate Islet Regenerative Functions
- Las células troncales de la sangre
- Engineered Human Stem Cell Microenvironments
- Changes in Cell Composition of Umbilical Cord Blood and Functional Activity of Hematopoietic Stem Cells during Cryogenic Storage and Repeated Freezing/Thawing Cycles
- Mesenchymal Stem Cell-Derived Microvesicles Support Ex Vivo Expansion of Cord Blood-Derived CD34+ Cells
- Quality and exploitation of umbilical cord blood for cell therapy: Are we beyond our capabilities?
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