'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?

Keywords

Mendelian randomization, Confounding, Observational study, Disease, Causal inference

References

• How to avoid bias when comparing bone marrow transplantation with chemotherapy.Richard Gray, K. Wheatley — 1991
• The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations.David Hallman, Eric Boerwinkle, N. Saha — 1991
• Contribution of Genetic Polymorphisms in Ethanol-Metabolizing Enzymes to Problem Drinking Behavior in Middle-Aged Japanese MenFang Sun, Ikiko Tsuritani, Yuichi Yamada — 2002
• MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.S. Féasson — 2002
• Biostatistical genetics and genetic epidemiologyRobert C. Elston, Jane M. Olson, Lyle J. Palmer — 2002
• Association study designs for complex diseasesLon R. Cardon, John I. Bell — 2001
• The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers.The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group — 1994
• Decreased serum homocysteine in pregnancy.Anders Andersson, Björn Hultberg, Lars Brattström — 1992
• Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).Richard S. Spielman, Ralph McGinnis, Warren J. Ewens — 1993
• Searching for genetic determinants in the new millenniumNeil Risch — 2000
• A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.Jiaying Chen, Meir J. Stampfer, Heather Hough — 1998
• Genetics and public health in the 21st centuryR. Skinner — 2001
• B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)Loı̈c Le Marchand, Timothy A. Donlon, Jean H. Hankin — 2002
• Haptoglobin polymorphism as a risk factor for coronary heart disease mortality.Dirk De Bacquer — 2001
• Mice without myoglobinDaniel J. Garry, George A. Ordway, John N. Lorenz — 1998
• The influence of HLA‐matched sibling donor availability on treatment outcome for patients with AML: an analysis of the AML 8A study of the EORTC Leukaemia Cooperative Group and GIMEMAS. Keating, Théo de Witte, Stefan Suciu — 1998
• Dietary and endogenous cholesterol and human cancer.Anthony J. McMichael, O M Jensen, D M Parkin — 1984
• The controversy over homocysteine and cardiovascular risk.Per Magne Ueland, Helga Refsum, Shirley A.A. Beresford — 2000
• Folic acid: influence on the outcome of pregnancy.Theresa O. Scholl, William G. Johnson — 2000
• Transgenic animals in integrative biology: approaches and interpretations of outcome.R. Sanders Williams, Peter D. Wagner — 2000

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• Effects of ginkgo extractMahmood M Althahabi, Yousuf, Ali K, Soni, Vikas — 2004
• Of Scaredy Cats and Cold Fish: The autonomic nervous system and behaviour in young childrenBram Dierckx — 2014
• Can better disease definition lead to cure?María José Ruiz Landáburu — 2004
• Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis正浩 矢部 — 2006
• Use of single-nucleotide polymorphisms in the search for genetic modifiers of the uremic phenotype.陽介 土田 — 2007
• Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption.Aidlin Darling Desing — 2007
• A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology.利英子 押木, 和宏 原田, 幸次郎 香川 — 2008
• Smoking and lung cancer: causality, Cornfield and an early observational meta-analysis.Liadh Kelly, Gareth J. F. Jones — 2009
• von Willebrand factor plasma levels, genetic variations and coronary heart disease in an older populationJ.E. van LOON, Maryam Kavousi, Frank W.G. Leebeek — 2012
• Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association.Vern Fotheringham, Chetan Sharma — 2013
• Fasting plasma glucose and incident heart failure risk: a population-based cohort study and new meta-analysis.Katie Williams — 2014
• Insight into rheumatological cause and effect through the use of Mendelian randomizationGregorio José Marcos Contreras, Francisco Javier Sanz García, Jesús Carlos Misiego Tejeda — 2016
• The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?A. David Smith — 2008
• Periodontitis and Systemic Disease: Association or Causality?Севир Павлович Голубятников — 2017
• The Mediterranean Diet Reduces the Risk and Mortality of the Prostate Cancer: A Narrative ReviewCatherine Westfall — 2017
• Functional genomic insights into the environmental determinants of mammalian fitnessSeung-Ho Song, Ju‐Hyun Lee, Ho-Won Park — 2018
• Causality between non‐alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes: A meta‐analysis with bias analysisAmy Morrison, Francesco Zaccardi, Kamlesh Khunti — 2018
• Homocysteine and small vessel stroke: A mendelian randomization analysisOmar Oulmehdi — 2019
• C-reactive protein polymorphisms influence serum CRP-levels independent of disease activity in ankylosing spondylitis.Theodora A. M. Claushuis, Mirjam K. de Vries, Mignon A. C. van der Weijden — 2015
• Mendelian randomisation: a tool for assessing causality in observational epidemiology.Nuala A. Sheehan, Meng Sha, Vanessa Didelez — 2011

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