The Worldwide Challenge of the Dementias: A Role for B Vitamins and Homocysteine?
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Summary
Large-scale randomized trials of homocysteine-lowering vitamins are needed to see if a proportion of dementia in the world can be prevented, and a definite causal pathway has yet to be shown.
- Type
- review
- Published
- 2008-06-01
- Cited by
- 231
- References
- 304
- Access
- Open access
- OpenAlex
- https://openalex.org/W27754594
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24402925
Keywords
Dementia, Homocysteine, B vitamins, Medicine, Population
References
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- Prevalence and severity of micronutrient deficiency: a cross-sectional study among adolescents in Sri Lanka.
- Reduced concentrations of several vitamins in normal weight patients with late-onset dementia of the Alzheimer type without vascular disease.
- Relationship of homocysteine and gene polymorphisms of its related metabolic enzymes with Alzheimer's disease.
- Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects.
- The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia
- Inflammatory proteins in plasma and the risk of dementia: the rotterdam study.
- Homocysteine: a marker for cognitive performance? A longitudinal follow-up study.
- Folic acid with or without vitamin B12 for cognition and dementia.
- Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress.
- Alcohol Intake and Risk of Dementia
Cited by
- High methionine, low folate and low vitamin B6/B12 (HM-LF-LV) diet causes neurodegeneration and subsequent short-term memory loss
- Mental energy: plausible neurological mechanisms and emerging research on the effects of natural dietary compounds
- High homocysteine and methylmalonate among demented and non-demented elderly receiving vitamin-B12 prescription and home help service
- Vascular mechanisms in dementia with special reference to folate and fibrinolysis
- Lysosomal cobalamin transport and its relevance to ageing and Alzheimer's disease
- Physical, psychological, demographic and modifiable risk factors for age related cognitive impairment associated with possible dementia and frailty
- Folate, vitamin B12, vitamin B6 and homocysteine: impact on pregnancy outcome.
- Altered cytological parameters in buccal cells from individuals with mild cognitive impairment and Alzheimer's disease
- Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study
- Vitamin B12 Levels in Alzheimer's Disease: Association with Clinical Features and Cytokine Production
- Occurrence and natural enhancement of folate in oats and barley
- Vitamins and Cognition
- Folate and vitamin B12: function and importance in cognitive development.
- Effect of Homocysteine Lowering Treatment on Cognitive Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Tofu Intake is Associated with Poor Cognitive Performance among Community-Dwelling Elderly in China
- Homocysteine and holotranscobalamin and the risk of Alzheimer disease
- Elevated plasma level of homocysteine is an independent risk factor for peripheral neuropathy.
- Plasma Thiols Levels in Alzheimer's Disease Mice under Diet-Induced Hyperhomocysteinemia: Effect of S-Adenosylmethionine and Superoxide-Dismutase Supplementation
- B vitamins and the aging brain.
- Impaired Lysosomal Cobalamin Transport in Alzheimer's Disease
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