Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.
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Summary
An important role for IL-15 in the pathogenesis of psoriasis is supported, as measured by epidermal thickness, grade of parakeratosis, and numbers of inflammatory cells and cycling keratinocytes, with a mAb generated using human immunoglobulin-transgenic mice.
- Type
- article
- Published
- 2003-11-15
- Cited by
- 197
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2104632655
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12105543
Keywords
Psoriasis, Cytokine, Immunology, Angiogenesis, Tumor necrosis factor alpha
References
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- Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor
- UM4D4+ (CDw60) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions.
- Diacylglycerol and Phosphatidate Generated by Phospholipases C and D, Respectively, Have Distinct Fatty Acid Compositions and Functions
Cited by
- Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐IL‐15 antibody Hu714MuXHu in cynomolgus monkeys
- NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27
- Développement d'immunocytokines à base d'interleukine 15 à visée thérapeutique
- Psoriasis-SCID-Maus-Modell
- Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases
- Statistical evaluation and experimental design of a psoriasis xenograft transplantation model treated with cyclosporin A
- Identification of a potent anti‐IL‐15 antibody with opposing mechanisms of action in vitro and in vivo
- Serum cytokine and chemokine profiles in patients with myasthenia gravis
- miR-15b is Downregulated in Myasthenia Gravis Patients and Directly Regulates the Expression of Interleukin-15 (IL-15) in Experimental Myasthenia Gravis Mice
- Pulmonale Expression und Regulation von IL-15 und den Rezeptoruntereinheiten IL-15Ra, IL 15Rb und gc in der durch Streptococcus pneumoniae induzierten Mauspneumonie
- Assessment of the therapeutic potential of the atypical chemokine receptor, D6
- Human Monoclonal Antibodies from Transgenic Mice
- Linfocitos T productores de IL-17 en patologías autoinmunes humanas
- Cytokine network in psoriasis revisited.
- Fas pulls the trigger on psoriasis.
- Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia.
- Targeting the interleukin-15 system in rheumatoid arthritis.
- Combination of TACI-IgG and anti-IL-15 treats murine lupus by reducing mature and memory B cells.
- Follow-up analysis of PSORS9 in 151 Chinese families confirmed the linkage to 4q31-32 and refined the evidence to the families of early-onset psoriasis.
- Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.
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