Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation
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Summary
It is revealed that LIMK2 expression and activity progressively decrease with advancing stage, and supports the hypothesis that there is selective pressure for reduced LIMK 2 expression in CRC to relieve negative constraints imposed upon gastrointestinal stem cells.
- Type
- article
- Published
- 2013-04-12
- Cited by
- 30
- References
- 55
- Access
- Open access
- OpenAlex
- https://openalex.org/W2104500470
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20750115
Keywords
Cancer research, Biology, Stem cell, Colorectal cancer, Cell growth
References
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- Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter
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- LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase‐type plasminogen activator system
- The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis.
- Cross‐talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility
- LIMK2 is a crucial regulator and effector of Aurora-A-kinase-mediated malignancy
Cited by
- Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway
- Afzelin exhibits anti-cancer activity against androgen-sensitive LNCaP and androgen-independent PC-3 prostate cancer cells through the inhibition of LIM domain kinase 1.
- Stem cell dynamics in homeostasis and cancer of the intestine
- Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells
- Elevated LIM kinase 1 in non-metastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation
- Molecular Pathways: Targeting the Kinase Effectors of RHO-Family GTPases
- Rho-associated coiled-coil containing kinases (ROCK)
- Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer
- Downregulation of LIMK1–ADF/cofilin by DADS inhibits the migration and invasion of colon cancer
- LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance
- Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions
- Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation
- A novel tumor‐based epithelial‐to‐mesenchymal transition score that associates with prognosis and metastasis in patients with Stage II/III colorectal cancer
- LIMK2 acts as an oncogene in bladder cancer and its functional SNP in the microRNA‐135a binding site affects bladder cancer risk
- Pimozide suppresses colorectal cancer via inhibition of Wnt/&bgr;‐catenin signaling pathway
- lncRNA LINC00460 promoted colorectal cancer cells metastasis via miR-939-5p sponging
- CD73 promotes tumor metastasis by modulating RICS/RhoA signaling and EMT in gastric cancer
- Downregulation of Rac1/PAK1/LIMK1/cofilin signaling pathway in colon cancer SW620 cells treated with Chlorin e6 photodynamic therapy.
- Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes
- Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the β‐catenin/ZEB1 axis
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