Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.
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Summary
The results show that NT3 can signal through TrkA and TrkB in neurons at certain stages of development and may explain why the phenotype of NT3−/− mice is more severe than that of trkC− /− mice.
- Type
- article
- Published
- 1995-09-01
- Cited by
- 170
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1527229950
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21018407
Keywords
Biology, Embryonic stem cell, Tropomyosin receptor kinase A, Tropomyosin receptor kinase B, Cell biology
References
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- The house mouse. Development and normal stages from fertilization to 4 weeks of age.
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- The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells.
- High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor
- Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements
- The role of neurotrophins in the developing nervous system.
- Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.
- The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.
- Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
- trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.
- Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
- The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.
- The trkB tyrosine protein kinase is a receptor for neurotrophin-4.
- NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
- The nerve growth factor family of receptors.
- Isoforms of the avian TrkC receptor: a novel kinase insertion dissociates transformation and process outgrowth from survival.
- trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.
Cited by
- In vivo analysis of Trk receptor signalling in the mouse nervous system
- Neurotrophine und aktivitätsabhängige synaptische Plastizität: Untersuchungen zum Ort und Mechanismus der regulierten Neurotrophin-Freisetzung in adenoviral transduzierten hippokampalen Primärkulturen
- Role of TrkB in neonatal ovary development
- A splice variant of the neurotrophin receptor trkB with increased specificity for brain‐derived neurotrophic factor.
- Effects of neurotrophin-3 (NT-3) administration on gene expression and dorsal root ganglion neuron loss and repair following axotomy in adult rats.
- Cellular aspects of trophic actions in the nervous system.
- Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase
- The Neurotrophin Receptor p75 Binds Neurotrophin-3 on Sympathetic Neurons with High Affinity and Specificity
- The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
- Role of the CaSR during development of cranial sensory neurons
- Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging
- Mechanisms of KCC2 upregulation during development
- Developmental changes in the neurotrophic factor survival requirements of peripheral nervous system neurons.
- The Survival-Promoting Effect of Glial Cell Line-Derived Neurotrophic Factor on Axotomized Corticospinal Neurons In Vivo Is Mediated by an Endogenous Brain-Derived Neurotrophic Factor Mechanism
- Retinoic Acid Combined with Neurotrophin-3 Enhances the Survival and Neurite Outgrowth of Embryonic Sympathetic Neurons
- Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia
- TrkA, But Not TrkC, Receptors Are Essential for Survival of Sympathetic Neurons In Vivo
- Neurotrophic factor regulation of gene expression in primary sensory neurons of the mouse
- Inhibition of sensory neuron apoptosis and prevention of loss by NT-3 administration following axotomy.
- Neurotrophic factors in action--new dogs and new tricks.
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