Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
Explore this paper's citation graph
Summary
Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases.
- Type
- article
- Published
- 2001-11-20
- Cited by
- 1,816
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W2100688137
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26037593
Keywords
Ubiquitin ligase, Muscle atrophy, Biology, Protein degradation, Ubiquitin
References
- Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats.
- Muscle Cachexia: Current Concepts of Intracellular Mechanisms and Molecular Regulation
- Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation.
- Regulation of different proteolytic pathways in skeletal muscle in fasting and diabetes mellitus.
- Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)
- Structural features in eukaryotic mRNAs that modulate the initiation of translation.
- Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy.
- Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states.
- Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles.
- Functional annotation of a full-length mouse cDNA collection
- Glucocorticoids and muscle catabolism.
- A family of mammalian F-box proteins.
- Ubiquitin gene expression in skeletal muscle is increased during sepsis: involvement of TNF-alpha but not IL-1.
- Endocrine regulation of protein breakdown in skeletal muscle.
- Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.
- What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?
- Regulation of components of the ubiquitin system by insulin-like growth factor I and growth hormone in skeletal muscle of rats made catabolic with dexamethasone.
- Different mechanisms of increased proteolysis in atrophy induced by denervation or unweighting of rat soleus muscle.
- Regulation of proteolysis
- The gene expression of ubiquitin ligase E3alpha is upregulated in skeletal muscle during sepsis in rats-potential role of glucocorticoids.
Cited by
- Cibles moléculaires de la myostatine impliquées dans l'hypertrophie musculaire chez la souris et le bovin
- Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase.
- New fundamental resistance exercise determinants of molecular and cellular muscle adaptations
- Short bouts of stretching increase myo‐D, myostatin and atrogin‐1 in rat soleus muscle
- The scientific rationale for optimizing nutritional support in cancer
- GSK-3beta activity is increased in skeletal muscle after burn injury in rats.
- The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.
- Fiber Type-Specific Nitric Oxide Protects Oxidative Myofibers against Cachectic Stimuli
- Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages
- MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis.
- Effects of Statins on Skeletal Muscle: A Perspective for Physical Therapists
- Mitochondrial adaptations in skeletal muscle to hindlimb unloading
- Mitogen-activated Protein Kinase Kinase 1 (MEK1) Stabilizes MyoD through Direct Phosphorylation at Tyrosine 156 During Myogenic Differentiation*
- Beneficial effects of endogenous and exogenous melatonin on neural reconstruction and functional recovery in an animal model of spinal cord injury
- A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.
- Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation*
- Protective effect of melatonin on TNF‐α‐induced muscle atrophy in L6 myotubes
- Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin‐proteasome pathways
- Increased expression of atrogenes and TWEAK family members after severe burn injury in non-burned human skeletal muscle
- Oxidative status and chymotrypsin-like activity in right and left ventricle hypertrophy in an experimental model of emphysema.
Related papers
- The poxvirus encoded ubiquitin ligase, p28, is regulated by proteasomal degradation and autoubiquitination.
- Promiscuous Interactions of gp78 E3 ligase CUE domain with polyubiquitin chains
- Ubiquitination and Degradation of Mutant p53
- The Antibiotic Treatment Index: A Novel Tool to Improve Antibiotic Resistance Monitoring
- The Ubiquitin E3 Ligase MaLUL2 Is Involved in High Temperature-Induced Green Ripening in Banana Fruit
- Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe
- Down-Regulating Destruction: Phosphorylation Regulates the E3 Ubiquitin Ligase Nedd4-2
- Ubiquitin-like Protein FAT10-mediated Proteasome Degradation
- HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates