Structural features in eukaryotic mRNAs that modulate the initiation of translation.
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Summary
In higher eukaryotes, translation is modulated at the level of initiation by five aspects of mRNA structure: (i) the m7G cap; (ii) the primary sequence or context surrounding the AUG codon; (iii) the position of the Aug codon, i.e. whether or not it s “first”; (iv) secondary structure both upstream and downstream from the AUU; and (v) leader length.
- Type
- article
- Published
- 1991-10-25
- Cited by
- 1,784
- References
- 4
- Access
- Open access
- OpenAlex
- https://openalex.org/W1546570611
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13805548
Keywords
Start codon, Ribosome, Eukaryotic translation, Biology, Protein subunit
References
- Both the 5' untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro
- Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control
- Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon
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