Second-generation PLINK: rising to the challenge of larger and richer datasets
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Summary
The second-generation versions of PLINK will offer dramatic improvements in performance and compatibility, and for the first time, users without access to high-end computing resources can perform several essential analyses of the feature-rich and very large genetic datasets coming into use.
- Type
- article
- Published
- 2014-10-17
- Cited by
- 11,580
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2099085143
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15089556
Keywords
Computer science, Codebase, Scalability, Genome-wide association study, Population
References
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- PATHWISE COORDINATE OPTIMIZATION
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- A Review of Family-Based Tests for Linkage Disequilibrium between a Quantitative Trait and a Genetic Marker
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- An integrated map of genetic variation from 1,092 human genomes
- Improving the Accuracy and Efficiency of Identity-by-Descent Detection in Population Data
- HAPGEN2: simulation of multiple disease SNPs
- Compression and fast retrieval of SNP data
Cited by
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- Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement
- Analysis of Heritability Using Genome-wide Data
- Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets.
- Systems Genetics Identifies a Novel Regulatory Domain of Amylose Synthesis1[OPEN]
- Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers
- FlashPCA2: principal component analysis of biobank-scale genotype datasets
- The last sea nomads of the Indonesian archipelago: genomic origins and dispersal
- Meta-analysis of sequence-based association studies across three cattle breeds reveals 25 QTL for fat and protein percentages in milk at nucleotide resolution
- Genome-wide association study of Hirschsprung disease detects a novel low-frequency variant at the RET locus
- Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population
- NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study
- Modeling SNP array ascertainment with Approximate Bayesian Computation for demographic inference
- Exploring Cuba’s population structure and demographic history using genome-wide data
- PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
- Population genetic analysis of aquaculture salmonid populations in China using a 57K rainbow trout SNP array
- Genome-wide association study reveals novel genetic locus associated with intra-individual variability in response time
- Genome‐wide meta‐analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci
- CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD
- Evaluating Neighborhood, Social, and Genetic Influences on Precursors of Alcohol Use Risk Behavior in African American Adolescents
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