Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA
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Summary
It is shown that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols and represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling and regenerative medicine.
- Type
- article
- Published
- 2010-09-30
- Cited by
- 2,634
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2098597036
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:230203
Keywords
Reprogramming, Induced pluripotent stem cell, Biology, Regenerative medicine, Somatic cell
References
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- Polycistronic Lentiviral Vector for “Hit and Run” Reprogramming of Adult Skin Fibroblasts to Induced Pluripotent Stem Cells
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- Reprogramming of human somatic cells to pluripotency with defined factors
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- 5'-Triphosphate RNA Is the Ligand for RIG-I
- Chimeric Receptor mRNA Transfection as a Tool to Generate Antineoplastic Lymphocytes
- Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.
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- 17-P022 Virus-free induction of pluripotency and subsequentexcision of reprogramming factors
- Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
Cited by
- Molecular and cellular basis of hematopoietic stem cells maintenance and differentiation
- Differentiation of Human Induced Pluripotent Stem Cells into a Keratinocyte Lineage
- Diagnostik und Behandlung des akuten Leberversagens
- Biology of the Mi-2/NuRD Complex in SLAC (Stemness, Longevity/Ageing, and Cancer)
- Comparing the reprogramming efficiency of mouse embryonic fibroblasts, mouse bone marrow mesenchymal stem cells and bone marrow mononuclear cells to iPSCs
- Human Amniotic Mesenchymal Stem Cell-Derived Induced Pluripotent Stem Cells May Generate a Universal Source of Cardiac Cells
- Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression
- Stem Cell Models for Drug Discovery and Toxicology Studies
- DNA Repair Mechanisms in Huntington’s Disease
- Structural immaturity of induced pluripotent stem cell-derived cardiomyocytes.
- AstraZeneca juggernaut heads for Cambridge
- Potential therapeutic applications of RNA cap analogs.
- Gene delivery in tissue engineering and regenerative medicine.
- THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
- Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond
- Inactivation of the p53–KLF4–CEBPA Axis in Acute Myeloid Leukemia
- Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury
- Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis
- Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process
- The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration
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