A Brilliant Disguise for Self RNA: 5′-end and Internal Modifications of Primary Transcripts Suppress Elements of Innate Immunity
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Summary
Results indicate that interferon inducible protein kinase PKR can also be activated by short stem-loop RNA in a 5’-triphosphate-dependent fashion, and Interestingly, self-RNAs have more nucleoside modifications than non-self RNAs.
- Type
- review
- Published
- 2008-07-01
- Cited by
- 75
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1975475128
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27224358
Keywords
Biology, Innate immune system, RNA, RNA silencing, TLR3
References
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Cited by
- Cell engineering with synthetic messenger RNA.
- Mechanistic Analysis of Activation of the Innate Immune Sensor PKR by Bacterial RNA
- Feeder-free reprogramming of human fibroblasts with messenger RNA.
- The ssRNA Genome of Human Rhinovirus Induces a Type I IFN Response but Fails to Induce Maturation in Human Monocyte-Derived Dendritic Cells1
- Switching Human Cell Fate: Reprogramming via pluripotency to adipogenesis
- Bacterial RNA induces myocyte cellular dysfunction through the activation of PKR.
- Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy
- Biomaterials for mRNA Delivery
- The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
- Function and Regulation of Retinoic Acid-Inducible Gene-I
- Induction of type I interferon by RNA viruses: cellular receptors and their substrates
- Conventional and unconventional mechanisms for capping viral mRNA
- 2'-5'-Oligoadenylate synthetase is activated by a specific RNA sequence motif.
- Interplay between viruses and host mRNA degradation
- dsRNA and the innate antiviral immune response
- Native Tertiary Structure and Nucleoside Modifications Suppress tRNA’s Intrinsic Ability to Activate the Innate Immune Sensor PKR
- Pathogen Associated Molecular Patterns, Pattern Recognition Receptorsand Pediatric Sepsis
- Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase
- Orchestration of the Activation of Protein Kinase R by the RNA-Binding Motif
- Conflict RNA modification, host-parasite co-evolution, and the origins of DNA and DNA-binding proteins1.
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