Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish.
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Summary
The results suggest that the negative regulatory roles of SOCS1a on JAK-STAT5 signaling may be involved in the suppression of the erythropoiesis and growth hormone activities, which was also reflected in the enhanced somatic growth performance observed in the heterozygous socs1a-deficient fish.
- Type
- article
- Published
- 2015-05-15
- Cited by
- 25
- References
- 43
- OpenAlex
- https://openalex.org/W2098022615
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7767786
Keywords
Zebrafish, Biology, STAT5, Internal medicine, Erythropoiesis
References
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- Energy Metabolism in the Liver
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- Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
- Recent advances in growth hormone signaling
- SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high‐fat‐diet‐fed mice
- In vivo insulin antagonism but evanescent in vitro tissue effect in rats with growth hormone-secreting tumors
- Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
- Impaired autophagy contributes to hepatocellular damage during ischemia/reperfusion: heme oxygenase-1 as a possible regulator.
- Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
- Studies on the effect of growth hormone in vivo and in vitro on lipogenic enzymes and transaminases in a teleost Anabas testudineus (BLOCH).
- Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish
- Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways.
- SOCS-1 Deficiency Does Not Prevent Diet-Induced Insulin Resistance
- Hypoxia-inducible factors and their roles in energy metabolism
- Influence of the crosstalk between growth hormone and insulin signalling on the modulation of insulin sensitivity.
- Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini.
- Regulation of lipoprotein lipase by Angptl4.
- Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis
Cited by
- Molecular characterization and immune response to lipopolysaccharide (LPS) of the suppressor of cytokine signaling (SOCS)-1, 2 and 3 genes in Nile tilapia (Oreochromis niloticus).
- Understanding and Editing the Zebrafish Genome.
- Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish
- Using zebrafish to model liver diseases-Where do we stand?
- Suppressor of cytokine signaling 3 (SOCS3) is related to pro‐inflammatory cytokine production and triglyceride deposition in turbot (Scophthalmus maximus)
- Effect of abiotic and biotic stress factors analysis using machine learning methods in zebrafish.
- Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish
- Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish.
- Designing future farmed fishes using genome editing
- Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
- Heterozygous depletion of pik3r1 improves growth and feed conversion efficiency in Gibel carp (Carassius gibelio)
- Sexual dimorphic effects of igf1 deficiency on metabolism in zebrafish
- Signaling pathways in obesity: mechanisms and therapeutic interventions
- Hepatic cytokine‐inducible SH2‐containing protein (CISH) regulates gluconeogenesis via cAMP‐responsive element binding protein (CREB)
- Programmed cell death and lipid metabolism of macrophages in NAFLD
- Zebrafish facilitate non‐alcoholic fatty liver disease research: Tools, models and applications
- The role of miRNA-26a-5p and target gene socs1a in flutolanil induced hepatotoxicity of zebrafish at environmental relevant levels.
- Harnessing CRISPR/Cas9 system to improve economic traits in aquaculture species
- 1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene
- Zebrafish Suppressor of Cytokine Signaling 4b (Socs4b) Is Dispensable for Development but May Regulate Epidermal Growth Factor Receptor Signaling
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